Bioreactor Synergy with 3D Scaffolds: New Era for Stem Cells Culture

Autor: Yang Kang, Shaoxiong Huang, Tianqi Yi, Jun Wu, Tiancheng Li, Guiting Liu, Yuxi Luo
Rok vydání: 2018
Předmět:
Zdroj: ACS Applied Bio Materials. 1:193-209
ISSN: 2576-6422
DOI: 10.1021/acsabm.8b00057
Popis: Because of unparalleled advantages over other cells, stem cells are widely used in genetic diagnosis, drug delivery, and regenerative medicine. However, because the content of stem cells in the organism is far from satisfactory, it is of great significance of stem cells to in vitro proliferation and differentiation. However, many stem cell cultures have low expansion efficiency and stem cells lose their value-adding ability and differentiation ability after many generations of culture. To solve these problems, people hope to more realistically simulate the microenvironment in which stem cells grow in vivo. Cell scaffolds gradually evolve from 2D structures to 3D structures. The addition of growth factors influences cell behavior from internal biochemical conditions and the development of smart bioreactors gradually make progress to more precise regulate the external conditions of stem cell. In this paper, the key factors for constructing the microenvironment of stem cell growth were analyzed, and we revie...
Databáze: OpenAIRE