Dynamic host immune response in virus-associated cancers

Autor: Song Cao, Kristine M. Wylie, Matt A. Wyczalkowski, Alla Karpova, Jessica Ley, Sam Sun, R. Jay Mashl, Wen-Wei Liang, Xiaowei Wang, Kimberly Johnson, John F. DiPersio, Hiram Gay, Lee Ratner, Feng Chen, Douglas R. Adkins, Li Ding
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Epstein-Barr Virus Infections
Virus Integration
Medicine (miscellaneous)
Biology
medicine.disease_cause
General Biochemistry
Genetics and Molecular Biology
Virus
Article
B7-H1 Antigen
03 medical and health sciences
0302 clinical medicine
Immune system
Downregulation and upregulation
Neoplasms
medicine
Biomarkers
Tumor
Humans
Gastrointestinal cancer
lcsh:QH301-705.5
030304 developmental biology
0303 health sciences
Gene Expression Profiling
Papillomavirus Infections
Cancer
medicine.disease
Cell Transformation
Viral
Programmed Cell Death 1 Ligand 2 Protein
Head and neck squamous-cell carcinoma
Immune checkpoint
3. Good health
Gene Expression Regulation
Neoplastic
lcsh:Biology (General)
030220 oncology & carcinogenesis
Host-Pathogen Interactions
Cancer research
Disease Susceptibility
General Agricultural and Biological Sciences
Carcinogenesis
Zdroj: Communications Biology, Vol 2, Iss 1, Pp 1-11 (2019)
Communications Biology
ISSN: 2399-3642
DOI: 10.1038/s42003-019-0352-3
Popis: Viruses drive carcinogenesis in human cancers through diverse mechanisms that have not been fully elucidated but include promoting immune escape. Here we investigated associations between virus-positivity and immune pathway alteration for 2009 tumors across six virus-related cancer types. Analysis revealed that for 3 of 72 human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSC) the HPV genome integrated in immune checkpoint genes PD-L1 or PD-L2, driving elevated expression in the corresponding gene. In addition to the previously described upregulation of the PD-1 immunosuppressive pathway in Epstein-Barr virus (EBV)-positive stomach tumors, we also observed upregulation of the PD-1 pathway in cytomegalovirus (CMV)-positive tumors. Furthermore, we found signatures of T-cell and B-cell response in HPV-positive HNSC and EBV-positive stomach tumors and HPV-positive HNSC patients were associated with better survival when T-cell signals were detected. Our work reveals that viral infection may recruit immune effector cells, and upregulate PD-1 and CTLA-4 immunosuppressive pathways.
Cao et al. show that human papillomavirus-positive, head and neck squamous cell carcinoma patients are associated with better survival when T-cells are activated. This study suggests that viral infection may recruit immune effector cells and that it may activate PD-1 and CTLA-4 immunosuppressive pathways.
Databáze: OpenAIRE
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