Role of catecholamines in glucagon-induced thermogenesis
| Autor: | Jean-Marc Pequignot, Hervé Barré, Jean-Louis Rouanet, Y. Filali-Zegzouti, H. Abdelmelek, J. M. Cottet-Emard |
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| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
Guanethidine Male medicine.medical_specialty Sympathetic Nervous System medicine.medical_treatment Intraperitoneal injection Down-Regulation Stimulation Fatty Acids Nonesterified Biology Glucagon Norepinephrine Adrenergic Agents Catecholamines Internal medicine medicine Animals Biological Psychiatry Catecholaminergic Thermogenesis Up-Regulation Psychiatry and Mental health Ducks Endocrinology Adipose Tissue Neurology Catecholamine Glucagon Injection Neurology (clinical) Energy Metabolism Injections Intraperitoneal medicine.drug |
| Zdroj: | Journal of Neural Transmission. 112:481-489 |
| ISSN: | 1435-1463 0300-9564 |
| Popis: | The present work was undertaken in order to investigate whether the observed thermogenesis following glucagon injection requires the participation of catecholamines. Our experiments aim at studying the effects of intraperitoneal injection of glucagon on metabolic rates, plasma catecholamine and fuel metabolites in guanethidine-treated ducklings reared at thermoneutrality (25 degrees C). The chronic guanethidine treatment induced a marked decrease in catecholamines levels in peripheral tissues (heart, muscle and intestine) but not in adrenals. At thermoneutrality, intraperitoneal injection of glucagon had lower thermogenic effects in guanethidine-treated compared to control ducklings. Glucagon injection elicited a concomitant increase of plasma norepinephrine, metabolic rate and energy metabolites in control ducklings, whereas in guanethidine-treated ducklings, the plasma catecholamines and metabolic rate did not undergo any consistent change. The thermogenic action of glucagon in birds involves at least the mobilization of lipids and catecholaminergic system stimulation. |
| Databáze: | OpenAIRE |
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