Elevated serum thyroglobulin levels at the time of ablative radioactive iodine therapy indicate a worse prognosis in thyroid cancer: an Australian retrospective cohort study
| Autor: | T J Matthews, Ash Gargya, Kan Gao, Michael Elliott, Jonathan R. Clark, Elizabeth L. Chua |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Pathology endocrine system diseases medicine.medical_treatment 030209 endocrinology & metabolism Gastroenterology Thyroglobulin Disease-Free Survival Thyroid carcinoma Iodine Radioisotopes 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Biomarkers Tumor Humans Thyroid Neoplasms Thyroid cancer Retrospective Studies Univariate analysis Surrogate endpoint business.industry Retrospective cohort study General Medicine Middle Aged medicine.disease Prognosis Confidence interval Otorhinolaryngology 030220 oncology & carcinogenesis Relative risk Thyroidectomy Female Neoplasm Recurrence Local business |
| Zdroj: | The Journal of laryngology and otology. 130 |
| ISSN: | 1748-5460 0022-2151 |
| Popis: | Background:Serum thyroglobulin is used as a surrogate marker for well-differentiated thyroid carcinoma recurrence. This study investigates whether thyroglobulin measured at the time of ablative radioactive iodine therapy predicts disease-free survival.Methods:A retrospective review was conducted of patients with well-differentiated thyroid carcinoma presenting from 1989 to 2010 at the Royal Prince Alfred Hospital, New South Wales, Australia. Disease-free survival of patients with a significantly elevated stimulated thyroglobulin level (27.5 µg/l or higher) at the time of ablative radioactive iodine therapy was compared to that of patients without a significantly elevated thyroglobulin level using univariate analysis.Results:Patients with a thyroglobulin level of 27.5 µg/l or higher had an increased relative risk of disease recurrence of 4.50 (95 per cent confidence interval = 1.35–15.04). If lateral neck dissection was required at the time of surgery, patients also had an increased relative risk of macroscopic disease recurrence of 4.94 (95 per cent confidence interval = 1.47–16.55).Conclusion:An elevated thyroglobulin level of 27.5 µg/l or higher at the time of ablative radioactive iodine therapy is a prognostic indicator for macroscopic disease recurrence in well-differentiated thyroid carcinoma. |
| Databáze: | OpenAIRE |
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