High Functionalization of 5-Nitro-1H-imidazole Derivatives: The TDAE Approach
| Autor: | Thierry Juspin, Thierry Terme, Laura Zink, Patrice Vanelle, Maxime D. Crozet |
|---|---|
| Přispěvatelé: | Chimie, biologie et radicaux libres - UMR 6517 (CBRL), Université de la Méditerranée - Aix-Marseille 2-Université Paul Cézanne - Aix-Marseille 3-Université de Provence - Aix-Marseille 1-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Radicalaire (ICR), Aix Marseille Université (AMU)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM) |
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
Magnetic Resonance Spectroscopy
Ethylene carbonyl derivatives Antiprotozoal Agents Pharmaceutical Science 010402 general chemistry 01 natural sciences Analytical Chemistry lcsh:QD241-441 Structure-Activity Relationship chemistry.chemical_compound lcsh:Organic chemistry Drug Discovery Humans Carbonyl derivatives Imidazole Organic chemistry [CHIM]Chemical Sciences Physical and Theoretical Chemistry Ester derivatives Protozoan Infections Ethanol 010405 organic chemistry TDAE Communication Organic Chemistry Bacterial Infections Ethylenes 5-nitro-1H-imidazole arylethanol 0104 chemical sciences 3. Good health chemistry Nitroimidazoles Chemistry (miscellaneous) Nitro Molecular Medicine Surface modification Chromatography Thin Layer Oxidation-Reduction Dimethylamines |
| Zdroj: | Molecules Molecules, 2011, 16 (8), pp.6883--6893. ⟨10.3390/molecules16086883⟩ Molecules, Vol 16, Iss 8, Pp 6883-6893 (2011) Molecules, MDPI, 2011, 16 (8), pp.6883--6893. ⟨10.3390/molecules16086883⟩ |
| ISSN: | 1420-3049 |
| DOI: | 10.3390/molecules16086883⟩ |
| Popis: | International audience; We report herein the synthesis of substituted 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl) phenyl]-1-arylethanols, ethyl 3-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)phenyl]-2-hydroxypropanoate and 2-[4-(1,2-dimethyl-5-nitro-1H-imidazol-4-yl)benzyl]-2-hydroxy-acenaphthy len-1(2H)-one from the reactions of 4-[4-(chloromethyl) phenyl]-1,2-dimethyl-5-nitro-1H-imidazole with various aromatic carbonyl and alpha-carbonyl ester derivatives using tetrakis(dimethylamino) ethylene (TDAE) methodology. |
| Databáze: | OpenAIRE |
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