Evaluating Rivastigmine in Mild-to-Moderate Parkinson’s Disease Dementia Using ADAS-Cog Items
| Autor: | Frederick A. Schmitt, Sibel Tekin, Kolbjørn Brønnick, Dag Aarsland, Xiangyi Meng, Jason T. Olin |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Parkinson's disease Phenylcarbamates Rivastigmine Neuropsychological Tests Placebo Severity of Illness Index behavioral disciplines and activities Cognition mental disorders Severity of illness medicine Humans Dementia Psychiatry Randomized Controlled Trials as Topic Retrospective Studies General Neuroscience Parkinson Disease Retrospective cohort study medicine.disease Psychiatry and Mental health Clinical Psychology Neuroprotective Agents Treatment Outcome Adas cog Physical therapy Geriatrics and Gerontology Cognition Disorders Psychology medicine.drug |
| Zdroj: | American Journal of Alzheimer's Disease & Other Dementiasr. 25:407-413 |
| ISSN: | 1938-2731 1533-3175 |
| DOI: | 10.1177/1533317510367486 |
| Popis: | Rivastigmine has been shown to improve cognition in patients with Parkinson’s disease dementia (PDD). To further explore the impact of anticholinesterase therapy on PDD, Alzheimer’s Disease Assessment Scale-cognitive subscale (ADAS-cog) items were assessed in a retrospective analysis of a 24-week, double-blind, placebo-controlled trial of rivastigmine. Mean changes from baseline at week 24 were calculated for ADAS-cog item scores and for 3 cognitive domain scores. A total of 362 patients were randomized to 3 to 12 mg/d rivastigmine capsules and 179 to placebo. Patients with PDD receiving rivastigmine improved versus placebo on items: word recall, following commands, ideational praxis, remembering test instructions, and comprehension of spoken language (P < .05), with standardized mean differences ranging from 0.04 to 0.30. Rivastigmine also showed significant effects versus placebo on all domains: memory, language, and praxis. The ADAS-cog is sensitive to broad cognitive changes in PDD. Overall, rivastigmine was associated with improvements on individual cognitive items and general cognitive domains. |
| Databáze: | OpenAIRE |
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