Novel Combinations of Vancomycin plus Ceftaroline or Oxacillin against Methicillin-Resistant Vancomycin-Intermediate Staphylococcus aureus (VISA) and Heterogeneous VISA
| Autor: | K. L. Newton, Poochit Nonejuie, Joe Pogliano, Michael J. Rybak, George Sakoulas, Brian J. Werth, K. P. Murray, Celine Vidaillac |
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| Rok vydání: | 2013 |
| Předmět: |
Boron Compounds
Methicillin-Resistant Staphylococcus aureus Vancomycin intermediate Staphylococcus aureus Microbial Sensitivity Tests medicine.disease_cause Microbiology Cell Wall Vancomycin medicine Pharmacology (medical) Boron difluoride Inverse correlation Fluorescent Dyes Oxacillin Pharmacology Chemistry Drug Synergism Vancomycin Resistance biochemical phenomena metabolism and nutrition Anti-Bacterial Agents Cephalosporins Drug Combinations Infectious Diseases Staphylococcus aureus medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 57:2376-2379 |
| ISSN: | 1098-6596 0066-4804 |
| DOI: | 10.1128/aac.02354-12 |
| Popis: | We demonstrated a significant inverse correlation between vancomycin and beta-lactam susceptibilities in vancomycin-intermediate Staphylococcus aureus (VISA) and heterogeneous VISA (hVISA) isolates. Using time-kill assays, vancomycin plus oxacillin or ceftaroline was synergistic against 3 of 5 VISA and 1 of 5 hVISA isolates or 5 of 5 VISA and 4 of 5 hVISA isolates, respectively. Beta-lactam exposure reduced overall vancomycin-Bodipy ( dipy rromethene bo ron difluoride [4,4-difluoro-4-bora-3a,4a-diaza- s -indacene] fluorescent dye) binding but may have improved vancomycin-cell wall interactions to improve vancomycin activity. Further research is warranted to elucidate the mechanism behind vancomycin and beta-lactam synergy. |
| Databáze: | OpenAIRE |
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