Synthesis and antitubercular evaluation of new 1,2,3-triazole derivatives of carbohydrates
| Autor: | Roberta C. N. R. Corrales, Fernando Rogério Pavan, Clarice Queico Fujimura Leite, Juliana Alves dos Santos, Rafael M. P. Dias, Adilson David da Silva |
|---|---|
| Přispěvatelé: | Universidade Estadual Paulista (Unesp), Universidade Federal de Juiz de Fora (UFJF) |
| Rok vydání: | 2013 |
| Předmět: |
chemistry.chemical_classification
Carbohydrate biology Chemistry Glycoconjugate Triazole Resazurin General Chemistry biology.organism_classification Antimicrobial Chemical synthesis Mycobacterium tuberculosis chemistry.chemical_compound Biochemistry 1 2 3-triazole Antitubercular activity Antibacterial activity Glycoconjugates Mycobacterium |
| Zdroj: | Currículo Lattes Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 2028-3997 |
| DOI: | 10.13171/mjc.1.6.2012.02.05.15 |
| Popis: | Made available in DSpace on 2016-01-28T16:56:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2012. Added 1 bitstream(s) on 2016-01-28T16:59:57Z : No. of bitstreams: 1 ISSN2028-3997-2012-01-06-281-288.pdf: 337911 bytes, checksum: b7fdf8cf2a719e14a265dcdb28740203 (MD5) Coordenação de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) We reported in this work the preparation of novel 1,4-disubstituted-1,2,3-triazoles derivatives from Dglucose and D-fructose and their in vitro antibacterial activity against Mycobacterium tuberculosis were evaluated. The chemical synthesis was performed based on the 1,3-dipolar cycloaddition reaction, and antimicrobial activity was determined based on Resazurin Microtiter Assay against Mycobacterium. None of the triazole glycoconjugates tested showed activity against these microorganisms. Universidade Federal de Juiz de Fora, Departamento de Química, Instituto de Ciências Exatas Universidade Estadual Paulista, Departamento de Ciências Biológicas, Faculdade de Ciências Farmacêuticas de Araraquara FAPESP: 2008/10390-2 FAPESP: 2009/06499-1 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|