Role of Epac in brain and heart
| Autor: | Anne‑Coline Laurent, Magali Breckler, Frank Lezoualc'h, Magali Berthouze |
|---|---|
| Přispěvatelé: | Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Paris-Sud - Paris 11 (UP11), Simon, Marie Francoise |
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
MESH: Cell Differentiation
medicine.medical_specialty MESH: Myocardium Heart Diseases GTPase [SDV.BC]Life Sciences [q-bio]/Cellular Biology Biology Biochemistry 03 medical and health sciences MESH: Brain 0302 clinical medicine Central Nervous System Diseases Internal medicine MESH: Cell Proliferation medicine Animals Guanine Nucleotide Exchange Factors Humans Myocyte MESH: Guanine Nucleotide Exchange Factors MESH: Animals Protein kinase A [SDV.BC] Life Sciences [q-bio]/Cellular Biology Cell Proliferation 030304 developmental biology 0303 health sciences MESH: Humans MESH: Heart Diseases Myocardium Brain Cell Differentiation Heart MESH: Central Nervous System Diseases 3. Good health Cell biology MESH: Heart Endocrinology Cardiac hypertrophy Second messenger system Rap1 Signalling pathways 030217 neurology & neurosurgery |
| Zdroj: | Biochemical Society Transactions Biochemical Society Transactions, Portland Press, 2012, 40 (1), pp.51-7. ⟨10.1042/BST20110642⟩ Biochemical Society Transactions, 2012, 40 (1), pp.51-7. ⟨10.1042/BST20110642⟩ |
| ISSN: | 0300-5127 1470-8752 |
| DOI: | 10.1042/BST20110642⟩ |
| Popis: | International audience; Epacs (exchange proteins directly activated by cAMP) are guanine-nucleotide-exchange factors for the Ras-like small GTPases Rap1 and Rap2. Epacs were discovered in 1998 as new sensors for the second messenger cAMP acting in parallel to PKA (protein kinase A). As cAMP regulates many important physiological functions in brain and heart, the existence of Epacs raises many questions regarding their role in these tissues. The present review focuses on the biological roles and signalling pathways of Epacs in neurons and cardiac myocytes. We discuss the potential involvement of Epacs in the manifestation of cardiac and central diseases such as cardiac hypertrophy and memory disorders. |
| Databáze: | OpenAIRE |
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