IL-4 and IL-17 Are Required for House Dust Mite-Driven Airway Hyperresponsiveness in Autoimmune Diabetes-Prone Non-Obese Diabetic Mice
| Autor: | Anne-Perrine Foray, Céline Dietrich, Coralie Pecquet, François Machavoine, Lucienne Chatenoud, Maria Leite-de-Moraes |
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| Přispěvatelé: | Institut Necker Enfants-Malades (INEM - UM 111 (UMR 8253 / U1151)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Dupuis, Christine, Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
[SDV]Life Sciences [q-bio] Nod Mice 0302 clinical medicine exacerbations Mice Inbred NOD Immunology and Allergy house dust mite Sensitization NOD mice Original Research Mice Inbred BALB C biology Interleukin-17 Pyroglyphidae respiratory system 3. Good health [SDV] Life Sciences [q-bio] IL-17 medicine.anatomical_structure [SDV.IMM]Life Sciences [q-bio]/Immunology Interleukin 17 lcsh:Immunologic diseases. Allergy [SDV.IMM] Life Sciences [q-bio]/Immunology Immunology 03 medical and health sciences Th2 Cells medicine Animals Interleukin 4 iNKT cells Asthma House dust mite business.industry IL-4 asthma biology.organism_classification medicine.disease Mucus respiratory tract diseases Disease Models Animal 030104 developmental biology 030228 respiratory system Th17 Cells Interleukin-4 airway hyperreactivity business lcsh:RC581-607 |
| Zdroj: | Frontiers in Immunology, Vol 11 (2021) Frontiers in Immunology Frontiers in Immunology, Frontiers, 2021, Online ahead of print. ⟨10.3389/fimmu.2020.595003⟩ Frontiers in Immunology, Frontiers, 2021, 11, Online ahead of print. ⟨10.3389/fimmu.2020.595003⟩ Frontiers in Immunology, 2021, 11, Online ahead of print. ⟨10.3389/fimmu.2020.595003⟩ |
| ISSN: | 1664-3224 |
| Popis: | Allergic asthma is characterized by airway inflammation with a Th2-type cytokine profile, hyper-IgE production, mucus hypersecretion, and airway hyperreactivity (AHR). It is increasingly recognized that asthma is a heterogeneous disease implicating complex immune mechanisms resulting in distinct endotypes observed in patients. In this study, we showed that non-obese diabetic (NOD) mice, which spontaneously develop autoimmune diabetes, undergo more severe allergic asthma airway inflammation and AHR than pro-Th2 BALB/c mice upon house dust mite (HDM) sensitization and challenge. The use of IL-4-deficient NOD mice and the in vivo neutralization of IL-17 demonstrated that both IL-4 and IL-17 are responsible by the exacerbated airway inflammation and AHR observed in NOD mice. Overall, our findings indicate that autoimmune diabetes-prone NOD mice might become useful as a new HDM-induced asthma model to elucidate allergic dysimmune mechanisms involving Th2 and Th17 responses that could better mimic some asthmatic endoytpes. |
| Databáze: | OpenAIRE |
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