Experimental hypergastrinaemia in the dog
| Autor: | H.M. Jennewein, Ganguli Pc, R. Siewert, F. Waldeck |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
medicine.medical_specialty
Duodenum Endocrinology Diabetes and Metabolism Clinical Biochemistry Anastomosis digestive system Biochemistry Endocrinology Dogs Molecular size Gastrin levels Internal medicine medicine Pyloric Antrum Animals Stomach Ulcer Antrum Gastrin Gastric Juice business.industry digestive oral and skin physiology Biochemistry (medical) Radioimmunoassay General Medicine digestive system diseases Gastric secretion Gastritis Female business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. 8(6) |
| ISSN: | 0018-5043 |
| Popis: | In order to investigate chronic hypergastrinaemia in dogs, studies with various excluded antrum preparations were performed. Gastric secretion was collected from denervated fundic pouches and gastrin levels were measured pre- and postoperatively by radioimmunoassay. In some samples the gastrins were separated according to their molecular size. Distinct hypergastrinaemia and acid hypersecretion developed in dogs where the antrum was excluded by a mucosal septum. Gastrin levels rose to 349 +/- 64 pg/ml (normal 76 +/- 19 pg/ml). Analysis of the gastrin pattern showed a predominance of smaller gastrin components. Although there was marked hypersecretion in most of the dogs with hypergastrinaemia, no close correlation was evident between these parameters. Some of the dogs with hypergastrinaemia developed anastomotic ulcers. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|