Short-term and long-term effects of major depressive disorder subtypes on obesity markers and impact of sex on these associations
| Autor: | Carole Clair, Aurélie M. Lasserre, Martin Preisig, Pedro Marques-Vidal, Marie-Pierre F. Strippoli, Clémentine Ottino, Peter Vollenweider, Mehdi Gholam, Caroline L. Vandeleur |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Longitudinal study medicine.medical_specialty Waist Population Body Mass Index Cohort Studies Internal medicine medicine Humans Obesity education Depression (differential diagnoses) Depressive Disorder Major education.field_of_study business.industry Depressive Disorder Major/epidemiology Female Middle Aged Obesity/epidemiology Waist Circumference Major depressive disorder Metabolic factors Sex differences Subtypes medicine.disease Psychiatry and Mental health Clinical Psychology business Body mass index Cohort study |
| Zdroj: | Journal of affective disorders, vol. 297, pp. 570-578 |
| Popis: | Background Only a few studies with conflicting results have examined the effects of sex on the prospective association between depression and subsequent obesity. Objective (1) To simultaneously assess the associations of the subtypes (atypical, melancholic, unspecified) of major depressive disorder (MDD) measured at baseline and subtypes of major depressive episodes (MDE) that emerged during a 5.5-year follow-up with changes in obesity markers (body mass index, waist circumference, fat mass) during this follow-up, and (2) to test the effect of sex on these associations. Methods Data from CoLaus|PsyCoLaus, a population-based cohort study including 2702 participants (50.1% women, mean age 49.6 years). Criteria for mental disorders were elicited using semi-structured interviews. Results History of atypical MDD at baseline was associated with a steeper increase in BMI and waist circumference, whereas atypical MDE during follow-up was associated with a steeper increase in the three studied obesity markers. Melancholic MDD at baseline was associated with a steeper increase in BMI. Several significant interactions with sex were found indicating higher increase in fat mass in men than in women following melancholic MDD reported at baseline, higher decrease in BMI and fat mass in women than in men related to melancholic MDE emerging during follow-up and higher increase in waist circumference in men than in women following unspecified MDD reported at baseline. Limitations Urban sample which may not be representative for the whole population. Conclusions Our results further advocate for the specific need of a thorough monitoring of obesity markers in patients with atypical MDD and suggest less favorable obesity marker changes mainly related to melancholic MDE in men. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|