Synthesis of Functionalized Carboranes as Potential Anticancer and BNCT Agents

Autor:	Venkata Jaganmohan Reddy, Matthew M. Roforth, Chalet Tan, M. Venkat Ram Reddy
Rok vydání:	2006
Předmět:	Boron Compounds Antineoplastic Agents Boron Neutron Capture Therapy DABCO Combinatorial chemistry Inorganic Chemistry chemistry.chemical_compound Isomerism chemistry Nucleophile Organic chemistry Molecule Breast cancer cells Physical and Theoretical Chemistry Isomerization Biological evaluation
Zdroj:	Inorganic Chemistry. 46:381-383
ISSN:	1520-510X 0020-1669
DOI:	10.1021/ic061948i
Popis:	Carboranyl aldehydes react with alpha,beta-unsaturated esters, ketones, and nitriles in the presence of DABCO to provide functionalized carboranyl alcohols in good yields. Acetates of these alcohols undergo a facile isomerization with a variety of nucleophiles and afford structurally interesting carboranes. Biological evaluation of these molecules exhibited impressive antiproliferative activity for brain and breast cancer cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d438028682e37c8c27135e667f41ba29 https://doi.org/10.1021/ic061948i Zobrazit plný text záznamu