Considerations for Clinical Trials Testing Radiotherapy Combined With Immunotherapy for Metastatic Disease
| Autor: | Nahum Puebla-Osorio, Hampartsaum Barsoumian, Quynh Nhu Nguyen, Pervin Hurmuz, Dawei Chen, Irwin I. Tendler, Nathan Comeaux, Joe Y. Chang, Chad Tang, Vivek Verma, Chike O. Abana, James W. Welsh, Duygu Sezen, Matthew S. Ning, Kewen He |
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| Rok vydání: | 2021 |
| Předmět: |
Oncology
Cancer Research medicine.medical_specialty medicine.medical_treatment Treatment outcome Disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Internal medicine Neoplasms medicine Humans Radiology Nuclear Medicine and imaging Clinical Trials as Topic Radiotherapy business.industry Cancer Immunotherapy medicine.disease Combined Modality Therapy Radiation therapy Clinical trial Diverse population 030220 oncology & carcinogenesis business |
| Zdroj: | Seminars in radiation oncology. 31(3) |
| ISSN: | 1532-9461 |
| Popis: | Metastatic cancer is inherently heterogeneous, and patients with metastatic disease can experience vastly different oncologic outcomes depending on several patient- and disease-specific characteristics. Designing trials for such a diverse population is challenging yet necessary to improve treatment outcomes for metastatic-previously thought to be incurable-disease. Here we review core considerations for designing and conducting clinical trials involving radiation therapy and immunotherapy for patients with metastatic cancer. |
| Databáze: | OpenAIRE |
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