Acute Renal Failure following Massive Mannitol Infusion
| Autor: | Luis Miguel González, Jose Sobrado, Beatriz Pazos, Argimiro Gándara, Angel J. Pérez-Pérez |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Diuresis Renal function Urine urologic and male genital diseases Renal Dialysis medicine Humans Mannitol Hypernatremia business.industry Osmolar Concentration Acute Kidney Injury medicine.disease Diuretics Osmotic Surgery Nephrology Anesthesia Renal physiology Hemodialysis Hyponatremia business Complication Kidney disease medicine.drug |
| Zdroj: | American Journal of Nephrology. 22:573-575 |
| ISSN: | 1421-9670 0250-8095 |
| DOI: | 10.1159/000065279 |
| Popis: | Mannitol overuse-induced acute renal failure (ARF) has rarely been described. We report four cases, all male, between the ages of 20 and 42 years, who developed acute renal failure (3 anuric, 1 nonoliguric) after receiving mannitol 1,172 ± 439 g (mean ± SD) during a time period of 58 ± 28 h. The infusion rate was 0.25 ± 0.02 g/kg/h. The onset of acute renal failure was detected 48 ± 22 h after infusion. In 2 of the 3 cases in which urinary cytology was evaluated, the presence of vacuole-containing renal tubular cells was observed. All patients had hyponatremia (120 ± 11 mEq/l), and hyperosmolality (osmolar gap 70 ± 11 mosm/kg water). No other factors could be pointed to as causing acute renal failure. In the 3 anuric cases in which hemodialysis was performed, immediate recovery of diuresis was observed. Two patients recovered renal function on the fifth and sixth days, and 2 died due to endocranial hypertension – one of them while recovering – on the fourth and sixth days. In the present report, mannitol-induced ARF occurred at clustered doses of 0.25 mg/kg/h. |
| Databáze: | OpenAIRE |
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