Chemotherapy-induced noncardiogenic pulmonary edema related to gemcitabine plus docetaxel combination with granulocyte colony-stimulating factor support
| Autor: | Briassoulis, E. Ch, Froudarakis, M. E., Milionis, Haralampos J., Peponis, I. A., Constantopoulos, S. H., Pavlidis, Nicholas |
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| Přispěvatelé: | Pavlidis, Nicholas [0000-0002-2195-9961], Milionis, Haralampos J. [0000-0003-3958-2266] |
| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Oncology
Dimetindene Breast Neoplasms/pathology Pulmonary toxicity Antimetabolites medicine.medical_treatment Lung edema Docetaxel Water retention Deoxycytidine Paclitaxel/*adverse effects/*analogs & derivatives Granulocyte colony-stimulating factor Breast cancer Adrenal Cortex Hormones Liver neoplasms Furosemide Pulmonary edema Phytogenic Granulocyte Colony-Stimulating Factor Antineoplastic agents Corticosteroid Respiratory function Noncardiogenic pulmonary edema Mastectomy Priority journal Deoxycytidine/*adverse effects/analogs & derivatives Respiratory disease Liver Neoplasms Antineoplastic Lymphatic Metastasis Granulocyte colony stimulating factor Cancer radiotherapy Combination Drug Therapy Combination Female Taxoids Cancer chemotherapy Fluorouracil Drug therapy Thorax radiography medicine.drug Human Pulmonary and Respiratory Medicine medicine.medical_specialty Antimetabolites Antineoplastic Neutropenia Paclitaxel Prednisolone Lymphatic metastasis Drug potentiation Antimetabolites Antineoplastic/*adverse effects Liver Neoplasms/drug therapy/secondary Breast Neoplasms Pulmonary Edema Adrenal Cortex Hormones/therapeutic use Antineoplastic Agents Phytogenic/*adverse effects Ranitidine Article Internal medicine Case report medicine Humans Chemotherapy Cyclophosphamide Aged Lung toxicity Pulmonary Edema/*chemically induced/drug therapy/radiography business.industry Granulocyte Colony-Stimulating Factor/*adverse effects Adrenal cortex hormones Cancer medicine.disease Antineoplastic Agents Phytogenic Gemcitabine Radiography Clinical feature Immunology Breast neoplasms Mitoxantrone business |
| Zdroj: | Respiration |
| Popis: | Several cancer therapeutic agents have been associated with pulmonary toxicity. Herein, we describe the case of a 73-year-old woman with breast cancer metastatic to the liver, who developed noncardiogenic pulmonary edema (NPE) while on treatment with gemcitabine plus docetaxel combination with granulocyte colony-stimulating factor (G-CSF) support. Gemcitabine, a deoxycytidine analogue, is reported to produce mild self-limiting and only occasionally severe pulmonary toxicity. The microtubule stabilizer docetaxel has been associated with water retention complications. The combination of these two agents has shown promising activity in several solid tumors and is in a phase of clinical development with prophylactic G-CSF in most of the trials due to the high rate of dose-limiting neutropenia observed with this combination. In our case pulmonary toxicity resolved rapidly following the administration of corticosteroids. A possible deleterious synergy of the compounds involved in this case is discussed and the medical literature on NPE related to cancer therapy is shortly reviewed. We conclude that NPE should always be considered in patients with respiratory function deterioration while on therapy with the gemcitabine-docetaxel combination and G-CSF. Corticosteroids can provide maximum benefit if started early upon diagnosis coupled with withdrawal of the causative drugs. Copyright © 2000 S. Karger AG, Basel. 67 6 680 683 |
| Databáze: | OpenAIRE |
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