Quantifying disease progression in amyotrophic lateral sclerosis using peripheral nerve sonography

Autor: Susanne Petri, Reinhard Dengler, Katja Kollewe, Stefanie Schreiber, Siegfried Kropf, Dorothea Henkel, Verena Dannhardt-Stieger, Grazyna Debska-Vielhaber, Susanne Abdulla, Judith Machts, Hans-Jochen Heinze, Peter J. Nestor, Stefan Vielhaber
Rok vydání: 2016
Předmět:
Male
medicine.medical_specialty
Physiology
Neural Conduction
Urology
Wrist
physiology [Neural Conduction]
diagnostic imaging [Peripheral Nerves]
030218 nuclear medicine & medical imaging
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Forearm
diagnostic imaging [Amyotrophic Lateral Sclerosis]
Physiology (medical)
medicine
Humans
ddc:610
physiopathology [Peripheral Nerves]
Peripheral Nerves
Amyotrophic lateral sclerosis
pathology [Amyotrophic Lateral Sclerosis]
Ulnar nerve
Aged
Ultrasonography
business.industry
methods [Ultrasonography]
Amyotrophic Lateral Sclerosis
Ultrasound
physiopathology [Amyotrophic Lateral Sclerosis]
Middle Aged
medicine.disease
innervation [Forearm]
Median nerve
Surgery
medicine.anatomical_structure
innervation [Wrist]
Cohort
Disease Progression
Biomarker (medicine)
Female
Neurology (clinical)
business
030217 neurology & neurosurgery
Follow-Up Studies
Zdroj: Muscle & nerve 54(3), 391-397 (2016). doi:10.1002/mus.25066
ISSN: 0148-639X
DOI: 10.1002/mus.25066
Popis: Introduction: In this study we investigated whether peripheral nerve sonography could be used as a biomarker to monitor disease progression in amyotrophic lateral sclerosis (ALS). Methods: In 37 patients, ulnar and median nerve cross-sectional area (CSA) was determined in at least 2 ultrasound sessions; mean follow-up was 14.5 months. Linear mixed-effects models were conducted to analyze time effects on CSA. Results: Ulnar nerve CSA declined significantly at a monthly rate of –0.04 mm (forearm) and –0.05 mm (wrist); the decrease was more pronounced when baseline CSA was greater. To detect a 50% treatment effect on ulnar nerve CSA, 332 patients would need to be entered in a hypothetical randomized, controlled clinical trial. Time had no significant impact on median nerve CSA. Conclusions: Distal ulnar nerve ultrasound may be a useful biomarker to monitor disease progression in ALS, especially as hypothetical treatment effects on CSA seem to be detectable in manageable cohort sizes. Muscle Nerve 54: 391–397, 2016.
Databáze: OpenAIRE
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