Sensors made of RNA: tailored ribozymes for detection of small organic molecules, metals, nucleic acids and proteins
| Autor: | Denise Strohbach, J. Wolf, Sabine Müller |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Xenobiology
Effector Materials Science (miscellaneous) Microchemistry technology industry and agriculture Ribozyme RNA Proteins macromolecular substances Biosensing Techniques Equipment Design Biology Molecular recognition Biochemistry Control and Systems Engineering Metals Nucleic Acids Nucleic acid biology.protein RNA Catalytic Electrical and Electronic Engineering Organic Chemicals Biosensor Function (biology) |
| Zdroj: | IEE proceedings. Nanobiotechnology. 153(2) |
| ISSN: | 1478-1581 |
| Popis: | Nucleic acids are well suited to serve as biosensors for the fast and reliable detection of small organic molecules, such as a number of metabolites or antibiotics, specific nucleic acid sequences, peptides, proteins or metal ions. One of the main advantages of using nucleic acids as biosensors is that they can be modulated to respond allosterically to specific effectors. Thus molecular recognition is transformed directly into a catalytic process with observable results. In particular, catalytic RNA structures, such as the hammerhead and hairpin ribozymes, have been used for biosensor engineering. The review reports on the function mode of nucleic acid biosensors and introduces recent developments and applications in the field. |
| Databáze: | OpenAIRE |
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