Serum lipid and leptin concentrations in hypopituitary patients with growth hormone deficiency
| Autor: | Turgut As, E. Sencer, Yusuf Orhan, S. Molvalilar, Nese Ozbey, Ekrem Algün |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Blood Glucose Leptin Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Medicine (miscellaneous) Blood lipids Thyroid Function Tests Body fat percentage Hypopituitarism Body Mass Index chemistry.chemical_compound High-density lipoprotein Internal medicine medicine Humans Nutrition and Dietetics medicine.diagnostic_test Triglyceride business.industry Lipids Endocrinology chemistry Growth Hormone Body Composition Female Lipid profile business Body mass index Bioelectrical impedance analysis |
| Zdroj: | International Journal of Obesity. 24:619-626 |
| ISSN: | 1476-5497 0307-0565 |
| DOI: | 10.1038/sj.ijo.0801206 |
| Popis: | OBJECTIVE: To investigate the effects of growth hormone (GH) deficiency on serum lipid and leptin concentrations in hypopituitary patients taking conventional replacement therapy and to determine the relations between leptin and gender and anthropometric and metabolic variables. SUBJECTS: Twenty-one GH deficient adult hypopituitary patients (15 women, six men) and 21 (14 women, seven men) age, sex and body mass index (BMI) matched healthy controls. MEASUREMENTS: After an overnight fast, anthropometric parameters were measured and body composition was determined by a bioelectrical impedance analyser. Venous blood samples were obtained for the measurements of glucose, total cholesterol, high density lipoprotein (HDL) cholesterol, triglyceride, intact insulin, insulin-like growth factor 1 (IGF-1) and leptin concentrations. Serum leptin and hormones were analysed by radioimmunoassay. RESULTS: Hypopituitary patients with GH deficiency showed significantly higher triglyceride, total and low density lipoprotein (LDL) cholesterol and lower HDL cholesterol concentrations on conventional replacement therapy. The unfavourable lipid profile was particularly evident in women. Significantly higher leptin concentrations were found in patients compared with healthy controls with similar body fat content (23.5±11.8 ng/ml vs 11.7±6.9 ng/ml, P=0.01). This difference remained significant even when leptin values were expressed in relation to fat mass percentage (0.79±0.40 vs 0.42±0.17 ng/ml%, P |
| Databáze: | OpenAIRE |
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