Early released lipid-soluble cardiodepressant factor and elevated oestrogenic substances in human septic shock
| Autor: | Vernimmen C, Auclair Mc, Emmanuel A. Nunez, N. Christeff, Alain Carli, Claire Carli-Vielle, C. Benassayag |
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| Rok vydání: | 1984 |
| Předmět: |
Adult
Male medicine.medical_specialty Chromatography Gas Hydrocortisone Estrone Clinical Biochemistry Radioimmunoassay Biochemistry Reference Values Internal medicine medicine Animals Humans In patient Aged Estradiol Septic shock Chemistry Heart Blood Proteins General Medicine Rat heart Middle Aged medicine.disease Lipids Shock Septic Rats Endocrinology Depression Chemical Shock (circulatory) medicine.symptom |
| Zdroj: | European Journal of Clinical Investigation. 14:288-294 |
| ISSN: | 1365-2362 0014-2972 |
| DOI: | 10.1111/j.1365-2362.1984.tb01183.x |
| Popis: | A cardiodepressant factor (CDF) able to decrease contractile activity of cultured rat heart cells was determined to be located in the lipid-soluble fraction of sera from men in septic shock. This heat-stable CDF has a molecular weight under 1000. Repeated fractionations of sera gave evidence of an oestrone-like chromatographic behaviour. Oestrone, oestradiol and cortisol were immunologically quantified in two groups (recovery and death) of men in septic shock. All of them were elevated in sera from patients with shock. Highest levels of oestrone 4330 pmol l-1 (SEM pL 851, n= 15), oestradiol 1030 pmol l-1 (SEM pL 220, n= 15) and cortisol 1096 pmol l-1 (SEM pL 94, n= 15), were found in patients who failed to recover from shock. However, oestrone levels were the most striking, especially in the male. This study gives evidence for a polarity relationship between the CDF and oestrone, but natural oestrone does not appear to be a direct CDF. Moreover, this study shows that radioimmunoassay of oestrone could be an important index evaluating the severeness of septic shock. |
| Databáze: | OpenAIRE |
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