Positive Correlation between H,K-Adenosine Triphosphatase Autoantibodies and Helicobacter pylori Antibodies in Patients with Pernicious Anemia
| Autor: | J.-Y. Ma, Kurt Borch, Sven Mårdh, L. Janzon, Sven Erik Sjöstrand |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Gastritis
Atrophic Male Swine Enzyme-Linked Immunosorbent Assay Cross Reactions Helicobacter Infections H(+)-K(+)-Exchanging ATPase Antigen Anemia Pernicious medicine Animals Humans Aged Autoantibodies Parietal cell pernicious anemia Helicobacter pylori biology business.industry Gastroenterology Autoantibody medicine.disease biology.organism_classification Antibodies Bacterial B vitamins medicine.anatomical_structure Immunology Female Triphosphatase Gastritis medicine.symptom business Epitope Mapping |
| Zdroj: | Scandinavian Journal of Gastroenterology. 29:961-965 |
| ISSN: | 1502-7708 0036-5521 |
| DOI: | 10.3109/00365529409094870 |
| Popis: | Helicobacter pylori is a major cause of gastritis, and the parietal cell H,K-adenosine triphosphatase (ATPase) is a major autoantigen in autoimmune atrophic corpus gastritis, which may eventually lead to pernicious anemia and/or neuropathy. Whether the bacterium induces the autoimmune response is unknown.By means of enzyme-linked immunosorbent assay the occurrence of antibodies against porcine H,K-ATPase and H. pylori was determined in sera from 30 patients with pernicious anemia.All sera scored positive against H,K-ATPase, and 25 (83%) scored positive against H. pylori. The titers of antibodies against both antigen preparations inversely correlated with the duration of disease. A possible common epitope in the antigen preparations was tested with a competition assay. There was no indication of a common epitope in either human or porcine H,K-ATPase and H. pylori.There was a positive correlation and a high incidence of antibodies against H,K-ATPase and H. pylori in sera from patients with pernicious anemia. These antibodies recognized different epitopes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|