Polyphenol‐Mediated Assembly of Proteins for Engineering Functional Materials
| Autor: | Gyeongwon Yun, Frank Caruso, Rui Guo, Joseph J. Richardson, Zhixing Lin, Jiajing Zhou, Yiyuan Han |
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| Rok vydání: | 2020 |
| Předmět: |
010405 organic chemistry
Chemistry Functional protein 02 engineering and technology General Medicine General Chemistry 021001 nanoscience & nanotechnology 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences Nanomaterials Structure and function chemistry.chemical_compound Cell targeting Biocatalysis Polyphenol Tannic acid Biophysics Denaturation (biochemistry) 0210 nano-technology |
| Zdroj: | Angewandte Chemie International Edition. 59:15618-15625 |
| ISSN: | 1521-3773 1433-7851 |
| Popis: | Functional materials composed of proteins have attracted much interest owing to the inherent and diverse functionality of proteins. However, establishing general techniques for assembling proteins into nanomaterials is challenging owing to the complex physicochemical nature and potential denaturation of proteins. Here, a simple, versatile strategy is introduced to fabricate functional protein assemblies through the interfacial assembly of proteins and polyphenols (e.g., tannic acid) on various substrates (organic, inorganic, and biological). The dominant interactions (hydrogen-bonding, hydrophobic, and ionic) between the proteins and tannic acid were elucidated; most proteins undergo multiple noncovalent stabilizing interactions with polyphenols, which can be used to engineer responsiveness into the assemblies. The proteins retain their structure and function within the assemblies, thereby enabling their use in various applications (e.g., catalysis, fluorescence imaging, and cell targeting). |
| Databáze: | OpenAIRE |
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