Response to Vitamin B12 and Folic Acid in Myalgic Encephalomyelitis and Fibromyalgia
| Autor: | Birgitta Peilot, Lena Halaouate, Michael Matousek, Carl-Gerhard Gottfries, Olof Zachrisson, Björn Regland, Sara Forsmark |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Fibromyalgia Prescription Drugs Genotype Dose Encephalomyelitis Pregabalin lcsh:Medicine Gastroenterology chemistry.chemical_compound Folic Acid Internal medicine Chronic fatigue syndrome Humans Medicine Duloxetine Vitamin B12 lcsh:Science Methylenetetrahydrofolate Reductase (NADPH2) Analgesics Fatigue Syndrome Chronic Multidisciplinary business.industry lcsh:R Thyroid medicine.disease Vitamin B 12 medicine.anatomical_structure Endocrinology chemistry Female lcsh:Q business Research Article medicine.drug |
| Zdroj: | PLoS ONE, Vol 10, Iss 4, p e0124648 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0124648 |
| Popis: | Background Patients with myalgic encephalomyelitis (ME, also called chronic fatigue syndrome) may respond most favorably to frequent vitamin B12 injections, in vital combination with oral folic acid. However, there is no established algorithm for individualized optimal dosages, and rate of improvement may differ considerably between responders. Objective To evaluate clinical data from patients with ME, with or without fibromyalgia, who had been on B12 injections at least once a week for six months and up to several years. Methods 38 patients were included in a cross-sectional survey. Based on a validated observer’s rating scale, they were divided into Good (n = 15) and Mild (n = 23) responders, and the two groups were compared from various clinical aspects. Results Good responders had used significantly more frequent injections (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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