An evaluation of Benemid p-(di-n-propylsulfamyl)-benzoid acid dosage schedule in children
| Autor: | Carolyn Axner, Edward J. Saltzman, Lewis L. Coriell, T. F. McNair Scott, Carmen Labra |
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| Rok vydání: | 1953 |
| Předmět: |
Kidney
Probenecid business.industry Sodium chemistry.chemical_element Penicillins Pharmacology Infections Excretion Penicillin Appointments and Schedules chemistry.chemical_compound medicine.anatomical_structure chemistry Pediatrics Perinatology and Child Health Toxicity medicine Uric acid business Benzoic acid medicine.drug |
| Zdroj: | The Journal of Pediatrics. 42:292-300 |
| ISSN: | 0022-3476 |
| Popis: | I T HAS been shown *, ~, a, 4 that a new derivative of benzoic acid, Benemid, ~ p(di-n-propytsulfamyl)-benzoic acid, effectively blocks the renal tubular transport mechanism for penicillin, phenosulfonpht halein, para-aminohippurate, and para-aminosalicylie acid. It also increases the excretion of uric acid and lowers the uric acid blood level2, ~ No toxicity was demonstrated by months of daily medication in dogs and the kidney tubular blocking effects were completely reversible upon discontinuing the Bencmid. In man, Boger and associates 7 have shown that a dose of 2 Gin. a day in adults may be continued ~or as long as nine months without evidence of renal toxicity. Benemid has all the pharmacologic actions of carinamide. However, it does not have the drawbacks of the latter drug, namely, the large amount required--up to 24 Gin. per day in the adult, which has to be given in divided doses every four hours, fairly frequent gastric distress on full dosage, ability to induce sensitivity as manifest by cutaneous rashes, and excretion as a sodium salt which removes considerable amounts of sodium from the body. s |
| Databáze: | OpenAIRE |
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