OPRM1 and EGFR contribute to skin pigmentation differences between Indigenous Americans and Europeans
| Autor: | Yann C. Klimentidis, Ellen E. Quillen, Miguel Eduardo Delgado-Burbano, Abigail W. Bigham, Mark Stoneking, Marc Bauchet, Franz X. Faust, Mark D. Shriver, Xianyun Mao |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Candidate gene
SLC45A2 Historia y Arqueología Genotype Biología Receptors Opioid mu Single-nucleotide polymorphism Skin Pigmentation SLC24A5 Biology Polymorphism Single Nucleotide Indigenous Indigenous Americans Historia Antiporters White People HUMANIDADES Human genetics Antigens Neoplasm Core haplotype Genetics Extended haplotype homozygosity SNP Humans Genetic Testing Genetics (clinical) Critical gap Antropología integumentary system Europeans Single Nucleotide polymorphism array Pigmentation gene Membrane Transport Proteins ErbB Receptors Haplotypes biology.protein Indians North American skin pigmentation sense organs |
| Zdroj: | SEDICI (UNLP) Universidad Nacional de La Plata instacron:UNLP |
| ISSN: | 1432-1203 |
| Popis: | Contemporary variation in skin pigmentation is the result of hundreds of thousands years of human evolution in new and changing environments. Previous studies have identified several genes involved in skin pigmentation differences among African, Asian, and European populations. However, none have examined skin pigmentation variation among Indigenous American populations, creating a critical gap in our understanding of skin pigmentation variation. This study investigates signatures of selection at 76 pigmentation candidate genes that may contribute to skin pigmentation differences between Indigenous Americans and Europeans. Analysis was performed on two samples of Indigenous Americans genotyped on genome-wide SNP arrays. Using four tests for natural selection—locus-specific branch length (LSBL), ratio of heterozygosities (lnRH), Tajima’s D difference, and extended haplotype homozygosity (EHH)—we identified 14 selection-nominated candidate genes (SNCGs). SNPs in each of the SNCGs were tested for association with skin pigmentation in 515 admixed Indigenous American and European individuals from regions of the Americas with high ground-level ultraviolet radiation. In addition to SLC24A5 and SLC45A2, genes previously associated with European/non-European differences in skin pigmentation, OPRM1 and EGFR were associated with variation in skin pigmentation in New World populations for the first time. Facultad de Ciencias Naturales y Museo |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink