Altered inhibition in the hippocampal neural networks after spreading depression
| Autor: | Ali Gorji, Erwin-Josef Speckmann, Walter Stummer, Homa Sadeghian, M. Khaleghi Ghadiri, Nikoo Ghaffarian, Masoud Mesgari |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Hippocampus Hippocampal formation Bicuculline Inhibitory postsynaptic potential Potassium Chloride Epilepsy medicine Extracellular Animals GABA-A Receptor Antagonists Rats Wistar CA1 Region Hippocampal gamma-Aminobutyric Acid Neurons Chemistry General Neuroscience Cortical Spreading Depression Neural Inhibition medicine.disease Inhibitory Postsynaptic Potentials Disinhibition Cortical spreading depression medicine.symptom Microelectrodes Neuroscience medicine.drug |
| Zdroj: | Neuroscience. 304:190-197 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2015.07.035 |
| Popis: | Prolonged neuronal depression after spreading depression (SD) is followed by a late cellular and synaptic hyperexcitability. Intra- and extracellular recordings of bioelectrical activities were performed in the rodent hippocampus to investigate the role of γ-aminobutyric acid (GABA)-mediated inhibition in the late hyperexcitable state of SD. The effect of KCl-induced negative DC potential shifts was investigated on extracellularly recorded paired-pulse depression (PPD) and bicuculline-induced afterdischarges as well as intracellularly recorded inhibitory post synaptic potentials (IPSPs) in the hippocampal CA1 area. The results revealed that SD decreased the degree of PPD, enhanced the number and duration of bicuculline-induced afterdischarges, and reduced the amplitude and duration of IPSPs. Application of low concentrations of bicuculline before the induction of SD enhanced the inhibitory effect of SD on IPSPs. Data indicate the contribution of GABA-mediated inhibition to SD-induced delayed hyperexcitability. Modulation of GABA function in the late hyperexcitability phase of SD may play a role in therapeutic management of SD-related neurological disorders. |
| Databáze: | OpenAIRE |
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