Immunohistochemical localization of cytokeratin 17 in transitional cell carcinomas of the human urinary tract
| Autor: | Tamara A. Tchipysheva, Vita I. Guelstein, Valeria D. Ermilova, Sergey M. Troyanovsky |
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| Rok vydání: | 1993 |
| Předmět: |
Carcinoma
Transitional Cell Urologic Neoplasms Pathology medicine.medical_specialty medicine.drug_class Fluorescent Antibody Technique Biology medicine.disease Monoclonal antibody Staining Diagnosis Differential Immunoenzyme Techniques Basal (phylogenetics) Cytokeratin Transitional cell carcinoma Biomarkers Tumor medicine Carcinoma Humans Keratins Immunohistochemistry Urothelium |
| Zdroj: | Virchows Archiv B Cell Pathology Including Molecular Pathology. 64:1-5 |
| ISSN: | 0042-6431 |
| DOI: | 10.1007/bf02915089 |
| Popis: | The expression of cytokeratin (CK) 17 was studied in 28 primary transitional cell carcinomas (TCCs) of the human urinary tract using CK 17-specific monoclonal antibody E3. While CK 17 was not detectable at all or only present in some areas of basal cells in normal--appearing urothelium, a certain subpopulation of cells of all G1 and G1/G2 TCCs examined (9 cases) stained positive for CK 17. These latter cells were either restricted to the basal compartment or located also in suprabasal layers exhibiting a decreasing intensity of immunoreactivity. CK 17 was seen in practically all cells in G2 and G2/G3 tumors (7 cases). In contrast, G3 TCCs and anaplastic carcinomas showed a highly variable CK 17 staining pattern ranging from completely negative to completely positive with several intermediate phenotypes. Our results indicate that CK 17 could be a useful marker for the progression of urinary tumors. |
| Databáze: | OpenAIRE |
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