An Inducible Endothelial Cell Surface Glycoprotein Mediates Melanoma Adhesion
| Autor: | Michael P. Bevilacqua, GE Rice |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Endothelium
medicine.medical_treatment Melanoma Experimental Biology Cell Adhesion Tumor Cells Cultured medicine Animals Humans Cell adhesion Melanoma Multidisciplinary Cell adhesion molecule Soluble cell adhesion molecules Antibodies Monoclonal Adhesion Molecular biology Molecular Weight Endothelial stem cell medicine.anatomical_structure Cytokine Colonic Neoplasms cardiovascular system Cancer research Neural cell adhesion molecule Endothelium Vascular Cell Adhesion Molecules |
| Zdroj: | Science. 246:1303-1306 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.2588007 |
| Popis: | Hematogenous metastasis requires the arrest and extravasation of blood-borne tumor cells, possibly involving direct adhesive interactions with vascular endothelium. Cytokine activation of cultured human endothelium increases adhesion of melanoma and carcinoma cell lines. An inducible 110-kD endothelial cell surface glycoprotein, designated INCAM-110, appears to mediate adhesion of melanoma cells. In addition, an inducible endothelial receptor for neutrophils, ELAM-1, supports the adhesion of a human colon carcinoma cell line. Thus, activation of vascular endothelium in vivo that results in increased expression of INCAM-110 and ELAM-1 may promote tumor cell adhesion and affect the incidence and distribution of metastases. |
| Databáze: | OpenAIRE |
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