Extensive Diversity of Ig-Superfamily Proteins in the Immune System of Insects
| Autor: | Masahiro Kondo, Dietmar Schmucker, Roland Püttmann-Holgado, David L. Lamar, Fiona L. Watson, Vivienne I. Rebel, Franziska Thomas, Michael Hughes |
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| Rok vydání: | 2005 |
| Předmět: |
Hemocytes
Insecta animal structures Fat Body Molecular Sequence Data Immunoglobulins Biology Cell Line Animals Genetically Modified DSCAM Immune system Phagocytosis Hemolymph Escherichia coli Animals Drosophila Proteins Protein Isoforms Amino Acid Sequence Receptors Immunologic Oligonucleotide Array Sequence Analysis Neurons Multidisciplinary Innate immune system Cell adhesion molecule fungi Alternative splicing Brain biology.organism_classification Immunity Innate Protein Structure Tertiary Cell biology Alternative Splicing Drosophila melanogaster Immunology biology.protein RNA Interference Antibody Cell Adhesion Molecules Drosophila Protein |
| Zdroj: | Science. 309:1874-1878 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.1116887 |
| Popis: | The extensive somatic diversification of immune receptors is a hallmark of higher vertebrates. However, whether molecular diversity contributes to immune protection in invertebrates is unknown. We present evidence that Drosophila immune-competent cells have the potential to express more than 18,000 isoforms of the immunoglobulin (Ig)-superfamily receptor Down syndrome cell adhesion molecule (Dscam). Secreted protein isoforms of Dscam were detected in the hemolymph, and hemocyte-specific loss of Dscam impaired the efficiency of phagocytic uptake of bacteria, possibly due to reduced bacterial binding. Importantly, the molecular diversity of Dscam transcripts generated through a mechanism of alternative splicing is highly conserved across major insect orders, suggesting an unsuspected molecular complexity of the innate immune system of insects. |
| Databáze: | OpenAIRE |
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