Apathy in schizophrenia as a deficit in the generation of options for action
| Autor: | Hartmann, Matthias N., Kluge, Agne, Kalis, Annemarie, Mojzisch, Andreas, Tobler, Philippe N., Kaiser, Stefan, LS Wijsgerige Ethiek, OFR - Ethics Institute |
|---|---|
| Přispěvatelé: | LS Wijsgerige Ethiek, OFR - Ethics Institute, University of Zurich, Hartmann, Matthias N |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Apathy Decision Making Cognitive effort Schizoaffective disorder Dysfunctional family 2738 Psychiatry and Mental Health Arts and Humanities (miscellaneous) 10007 Department of Economics Developmental and Educational Psychology medicine Humans Verbal fluency test Option generation Psychiatry Biological Psychiatry Mechanism (biology) Decision Making/physiology Schizophrenia/physiopathology medicine.disease 330 Economics Clinical Psychology Psychiatry and Mental health Cognitive remediation therapy Schizophrenia Apathy/physiology Female Negative symptoms medicine.symptom Psychology 2803 Biological Psychiatry Goals Decision-making Psychopathology Clinical psychology |
| Zdroj: | Journal of Abnormal Psychology, 124(2), 309. American Psychological Association Journal of Abnormal Psychology, Vol. 124, No 2 (2015) pp. 309-18 Journal of abnormal psychology |
| ISSN: | 1939-1846 0021-843X |
| Popis: | Negative symptoms are a core feature of schizophrenia and have been grouped into 2 factors: a motivational factor, which we refer to as apathy, and a diminished expression factor. Recent studies have shown that apathy is closely linked to functional outcome. However, knowledge about its mechanisms and its relation to decision-making is limited. In the current study, we examined whether apathy in schizophrenia is associated with predecisional deficits, that is, deficits in the generation of options for action. We applied verbal protocol analysis to investigate the quantity of options generated in ill-structured real world scenarios in 30 patients with schizophrenia or schizoaffective disorder and 21 healthy control participants. Patients generated significantly fewer options than control participants and clinical apathy ratings correlated negatively with the quantity of generated options. We show that the association between measures of psychopathology and option generation is most pronounced in regard to apathy symptoms and that it is only partially mediated by deficits in verbal fluency. This study provides empirical support for dysfunctional option generation as a possible mechanism for apathy in schizophrenia. Our data emphasize the potential importance of predecisional stages in the development and persistence of apathy symptoms in neuropsychiatric disorders and might also inform the development of novel treatment options in the realm of cognitive remediation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|