Effect of intrathecal baclofen on gait control in human hereditary spastic paraparesis

Autor: Bernard Dan, Ana Bengoetxea, Guy Cheron, Ethel Bouillot
Rok vydání: 2000
Předmět:
Muscle Relaxants
Central -- therapeutic use
Adult
medicine.medical_specialty
Baclofen
Time Factors
Paraparesis
Spastic -- physiopathology
Hereditary spastic paraplegia
Muscle Relaxants
Central -- pharmacology
Muscle Relaxants
Central -- administration & dosage
Baclofen -- administration & dosage
Thigh
Baclofen -- pharmacology
Paraparesis
Spastic -- genetics
Central nervous system disease
chemistry.chemical_compound
Bolus (medicine)
Gait (human)
Locomotion -- drug effects
Reference Values
Baclofen -- therapeutic use
medicine
Humans
Biomechanics
Gait
Injections
Spinal
Gait -- drug effects
business.industry
Muscle Relaxants
Central
musculoskeletal
neural
and ocular physiology
General Neuroscience
Spastic paraparesis
Sciences bio-médicales et agricoles
medicine.disease
Surgery
Biomechanical Phenomena
body regions
medicine.anatomical_structure
nervous system
chemistry
Anesthesia
Paraparesis
Spastic
Reflex
business
Locomotion
Zdroj: Neuroscience letters, 280 (3
ISSN: 0304-3940
Popis: The covariation between thigh, shank and foot elevation angles during locomotion was analysed by means of orthogonal planar regression in a patient with pure hereditary spastic paraparesis before and after an intrathecal bolus of baclofen and in seven healthy subjects. The size, shape and spatial orientation of the loop defining patient's planar covariation (thigh angle vs. shank angle vs. foot angle) significantly differed from the controls' before baclofen, whereas these features resumed normal characteristics after baclofen injection. This shows that alteration of the control of phase coupling for the co-ordination of lower limb segments in human gait by increased spinal reflexes can be reversed by intrathecal baclofen injection.
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
info:eu-repo/semantics/published
Databáze: OpenAIRE
Externí odkaz: