Modulation of High-Density Lipoprotein Function via Cardiac Rehabilitation

Autor: Seimi Satomi-Kobayashi, Tatsuro Ishida
Jazyk: angličtina
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
medicine.medical_treatment
030204 cardiovascular system & hematology
chemistry.chemical_compound
0302 clinical medicine
High-density lipoprotein
Rehabilitation
Cardiac Rehabilitation
Anticholesteremic Agents
Middle Aged
Cholesterol efflux capacity
Prognosis
Cholesterol
Editorial
Modulation
cardiovascular system
Cardiology
lipids (amino acids
peptides
and proteins)
Original Article
Female
Lipoproteins
HDL
Cardiology and Cardiovascular Medicine
Acute coronary syndrome
medicine.medical_specialty
03 medical and health sciences
Text mining
Internal medicine
Internal Medicine
medicine
Humans
Acute Coronary Syndrome
Aged
Retrospective Studies
business.industry
Aryldialkylphosphatase
Biochemistry (medical)
Cholesterol
HDL
nutritional and metabolic diseases
medicine.disease
030104 developmental biology
chemistry
Physical therapy
Apolipoprotein A1
Paraoxonase-1 activity
business
Function (biology)
Biomarkers
Follow-Up Studies
Zdroj: Journal of Atherosclerosis and Thrombosis
ISSN: 1340-3478
Popis: Aims: We evaluated whether exercised-based cardiac rehabilitation (CR) can ameliorate the HDL function, i.e., cholesterol efflux capacity (CEC) and paraoxonase-1 activity in patients with acute coronary syndrome (ACS). Methods: This study is a retrospective analysis of stored serum from patients with ACS following successful percutaneous coronary intervention. The CEC, measured by a cell-based ex vivo assay using apolipoprotein B-depleted serum and 3H-cholesterol labeled macrophages and arylesterase activity (AREA) at the onset or early phase of ACS, and the follow-up periods were compared between 69 patients who completed the five-month outpatient CR program (CR group) and 15 patients who did not participate and/or dropped out from CR program (non-CR group). Results: Apolipoprotein A-I (apoA-I) and CEC significantly increased by 4.0% and 9.4%, respectively, in the CR group, whereas HDL-cholesterol and AREA were not changed during the follow-up periods in both groups. Among CR patients, the CEC significantly increased, irrespective of the different statin treatment, while HDL-cholesterol and apoA-I significantly increased in patients treated with rosuvastatin or pitavastatin. Although CEC and AREA were significantly correlated each other, there is a discordance between CEC and AREA for their correlations with other biomarkers. Both CEC and AREA were significantly correlated with apoA-I rather than HDL-cholesterol. Changes in CEC and those in AREA were significantly correlated with those in apoA-I (rho = 0.328, p = 0.002, and rho = 0.428, p < 0.0001, respectively) greater than those in HDL-cholesterol (rho = 0.312, p = 0.0042, and rho = 0.343, p = 0.003, respectively). Conclusions: CR can improve HDL function, and it is beneficial for secondary prevention.
Databáze: OpenAIRE
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