Metabolic syndrome affects narrow-band UVB phototherapy response in patients with psoriasis
| Autor: | Fan Jianfeng, Xie Fang, Li Chengxin, Hao Tian, Ding Xiangyu, Zhang Xiaoning, Li Hengjin, Zhou Yong, Gong Long, Yang Yi, Wang Wenjuan, Wang Rui |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Observational Study Narrow band uvb Elevated blood 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Psoriasis Epidemiology medicine NB-UVB Humans In patient systemic inflammation Metabolic Syndrome integumentary system treatment Interleukin-6 business.industry Interleukin-17 psoriasis General Medicine Phototherapy medicine.disease Dermatology Obesity 030220 oncology & carcinogenesis Female Metabolic syndrome business Biomarkers Dyslipidemia Research Article |
| Zdroj: | Medicine |
| ISSN: | 0025-7974 |
| Popis: | Psoriasis is a chronic inflammatory skin disease. Metabolic syndrome (MS) is a combination of central obesity, dyslipidemia, glucose intolerance, and elevated blood pressure. Many epidemiological surveys have revealed the association of psoriasis with MS. Narrowband ultraviolet radiation b (NB-UVB) is an effective and widely used treatment for psoriasis. The purpose of this study was to investigate whether the presence of MS in patient with psoriasis affects NB-UVB treatment and whether this syndrome correlates with systemic inflammation. From June 2016 to December 2016, 243 adults with a diagnosis of psoriasis vulgaris eligible to treatment with NB-UVB were admitted to the phototherapy unit of Dermatology department, Chinese PLA General Hospital. Fifty-five included patients were grouped based on the presence of MS. They accepted the treatment of NB-UVB and the following data were collected: serum levels of IL-17 (interleukin), TNF-α (tumor necrosis factor) and IL-6, Psoriasis Area and Severity Index (PASI) scores before and after 10 sections of NB-UVB treatment. Significant PASI improvement was observed in psoriatic patients without MS after 10 sections of phototherapy, while patients with MS showed a less improvement (P |
| Databáze: | OpenAIRE |
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