MiR-150 promotes gastric cancer proliferation by negatively regulating the pro-apoptotic gene EGR2
| Autor: | Yan Pan, Kai Li, Bin Feng, Gui Ren, Yuanyuan Lu, Xin Wang, Zengfu Xue, Zhiping Yang, Qiong Wu, Guanhong Luo, Tao Su, Haifeng Jin, Daiming Fan |
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| Rok vydání: | 2009 |
| Předmět: |
Molecular Sequence Data
Biophysics Mice Nude Apoptosis Biology medicine.disease_cause Biochemistry Mice Stomach Neoplasms miR-150 Cell Line Tumor microRNA medicine Animals Humans Luciferase Molecular Biology Early Growth Response Protein 2 Cell Proliferation Base Sequence Cell growth Carcinoma Cancer Cell Biology medicine.disease Molecular biology Gene Expression Regulation Neoplastic MicroRNAs Cancer cell Cancer research Ectopic expression Carcinogenesis |
| Zdroj: | Biochemical and biophysical research communications. 392(3) |
| ISSN: | 1090-2104 |
| Popis: | Accumulating evidence suggests small non-coding RNAs (microRNAs) play important roles in human cancer progression. In the present study, we found miR-150 was overexpressed in gastric cancer cell lines and tissues. Ectopic expression of miR-150 promoted tumorigenesis and proliferation of gastric cancer cells. Luciferase reporter assay demonstrated that EGR2 was a direct target of miR-150. Collectively, our study demonstrated that overexpression of miR-150 in gastric cancer could promote proliferation and growth of cancer cells at least partially through directly targeting the tumor-suppressor EGR2, suggesting a potential strategy for the development of miRNA-based treatment of gastric cancer. |
| Databáze: | OpenAIRE |
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