Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
| Autor: | Marjo-Riitta Järvelin, Catherine Allard, Andres Cardenas, Olivia Solomon, Barbara Heude, Vincent W. V. Jaddoe, Wilfried Karmaus, Terence Dwyer, Katri Räikkönen, Darina Czamara, Olena Gruzieva, Isabella Annesi-Maesano, Manolis Kogevinas, Simon Kebede Merid, Hongmei Zhang, Wenche Nystad, Florianne O L Vehmeijer, Erik Melén, Susan Ewart, Lu Gao, Michelle Plusquin, Sarah E. Reese, Munawar Hussain Soomro, Marie-France Hivert, Zdenko Herceg, Andrea A. Baccarelli, Janine F. Felix, Luigi Bouchard, Göran Pershagen, Jordi Sunyer, Alexei Novoloaca, Joseph L. Wiemels, Elisabeth B. Binder, John P. Newnham, Thorkild I. A. Sørensen, Sheryl L. Rifas-Shiman, Ellen A. Nohr, Nabila Kazmi, Carrie V. Breton, Ashok Kumar, Juha Kere, Nina Holland, Josep M. Antó, Debbie A Lawlor, Karen Huen, Rae-Chi Huang, Inger Kull, Brenda Eskenazi, Paolo Vineis, Matthias Wielscher, Monica Cheng Munthe-Kaas, Catarina Almqvist, Cilla Söderhäll, Lucas A. Salas, Jean Bousquet, Alvin T. Kho, Patrice Perron, Petter Brodin, Martine Vrijheid, Kelan G. Tantisira, Per Magnus, Scott T. Weiss, Faisal I. Rezwan, Nour Baïz, Stephanie J. London, Gemma C Sharp, Phillip E. Melton, Emily Oken, Luigi Gagliardi, John W. Holloway, Gerard H. Koppelman, Siri E. Håberg, Caroline L Relton, Leanne K. Küpers, Denise Anderson, Jari Lahti, Tim S. Nawrot, Mariona Bustamante, Priyadarshini Kachroo, S. Hasan Arshad, Dawn L. DeMeo, Liesbeth Duijts, Sylvain Sebert, Shanshan Zhao, Eva Corpeleijn, Judith M. Vonk, Christian M. Page, Harold Snieder, Pooja Jain, Akram Ghantous, Anna Bergström, Cheng-Jian Xu, Ritu Roy |
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| Přispěvatelé: | Rezwan, Faisal Ibne/0000-0001-9921-222X, Holloway, John/0000-0001-9998-0464, Lawlor, Debbie A/0000-0002-6793-2262, Salas, Lucas A/0000-0002-2279-4097, Cardenas, Andres/0000-0003-2284-3298, Sharp, Gemma/0000-0003-2906-4035, Lifestyle Medicine (LM), Reproductive Origins of Adult Health and Disease (ROAHD), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Doctoral Programme in Cognition, Learning, Instruction and Communication, Department of Psychology and Logopedics, Developmental Psychology Research Group, Faculty of Medicine, University of Helsinki, STEMM - Stem Cells and Metabolism Research Program, Juha Kere / Principal Investigator, Research Programs Unit, HUS Helsinki and Uusimaa Hospital District, UNIVERSITY OF OULU, Salvy-Córdoba, Nathalie, Karolinska Institutet [Stockholm], Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, International Agency for Cancer Research (IACR), MRC Integrative Epidemiology Unit [Bristol, Royaume-Uni] (MRC IEU), University of Bristol [Bristol], Bristol Medical School, Wageningen University and Research [Wageningen] (WUR), University of Groningen [Groningen], Boston Children's Hospital, Harvard Medical School [Boston] (HMS), University of California [San Francisco] (UC San Francisco), University of California (UC), Helen Diller Family Comprehensive Cancer Center [San Francisco], Southern California University of Health Sciences (SCU), Epidemiology of Allergic and Respiratory Diseases Department [iPlesp] (EPAR), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), NIHR Biomedical Research Centre [London], Guy's and St Thomas' NHS Foundation Trust-King‘s College London, Imperial College London, Hasselt University (UHasselt), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), IMIM-Hospital del Mar, Generalitat de Catalunya, Faculté de médecine et des sciences de la santé [Sherbrooke] (UdeS), Université de Sherbrooke (UdeS), Erasmus University Medical Center [Rotterdam] (Erasmus MC), Geisel School of Medicine at Dartmouth, Cranfield University, University of Memphis (U of M), University of Oulu, Department of Biology and Biocenter Oulu, Max Planck Institute of Psychiatry, Max-Planck-Gesellschaft, Harvard Pilgrim Health Care Institute, Curtin University [Bentley, WA, Australie], The University of Western Australia (UWA), NIHR Bristol Biomedical Research Centre, Centre for Occupational and Environmental Medicine [Stockholm, Sweden] (Region Stockholm), University of Southern California (USC), University of California [Berkeley] (UC Berkeley), USL Tuscany Northwest, NIHR Health Protection Research Unit, Partenaires INRAE, University Hospitals Leuven [Leuven], University Medical Center Groningen [Groningen] (UMCG), CHUS – Centre Hospitalier Universitaire de Sherbrooke [Sherbrooke, QC, Canada], University of Southern Denmark (SDU), Michigan State University [East Lansing], Michigan State University System, National Institute of Environmental Health Sciences [Durham] (NIEHS-NIH), National Institutes of Health [Bethesda] (NIH), Norwegian Institute of Public Health [Oslo] (NIPH), Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Turku Institute for Advanced Studies, Columbia Mailman School of Public Health, Columbia University [New York], Telethon KIDS Institute, Brigham and Women’s Hospital [Boston, MA], Département des Sciences Fondamentales [Saguenay, QC, Canada], Université du Québec à Chicoutimi (UQAC), Novo Nordisk Foundation Center for Basic Metabolic Research (CBMR), Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), University of Copenhagen = Københavns Universitet (UCPH), University of Southampton, The David Hide Asthma and Allergy Research Centre, St Mary's Hospital-University Hospital Southampton NHS Foundation Trust, University Hospital Southampton NHS Foundation Trust, Nuffield Department of Women's and Reproductive Health (NDWRH), University of Oxford- John Radcliffe Hospital [Oxford University Hospital], Murdoch Children's Research Institute (MCRI), Emory University School of Medicine, Emory University [Atlanta, GA], Brigham and Women's Hospital [Boston], Karolinska Institutet Science Park, Sachs' Children's Hospital, Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Research Team on Early life Origins of Health (EarOH), Oslo University Hospital [Oslo], Brigham & Women’s Hospital [Boston] (BWH), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], University of Basel (Unibas), Swiss Tropical and Public Health Institute [Basel], Astrid Lindgren Children's Hospital, Karolinska University Hospital [Stockholm], School of Public Health [Berkeley], University of California (UC)-University of California (UC), Beatrix Children's Hospital, Folkhälsan Research Center, Faculty of Medecine [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Science for Life Laboratory, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-17165 Sweden., Massachusetts General Hospital [Boston], Erasmus MC other, Pediatrics |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Male
Physiology MESH: Epigenome Fetal Development Epigenome 0302 clinical medicine MESH: Child MATERNAL SMOKING CORD BLOOD Aetiology Child Lung Genetics & Heredity 1184 Genetics developmental biology physiology ASSOCIATION ALSPAC 3. Good health Child Preschool 030220 oncology & carcinogenesis Epigenetics Infant Premature Clinical Sciences Development 03 medical and health sciences Clinical Research Genetics Humans Transcriptomics Premature Molecular Biology MESH: Adolescent 0604 Genetics Pregnancy MESH: Humans Science & Technology MESH: Child Preschool lcsh:R PRENATAL ARSENIC EXPOSURE Infant DNA DNA Methylation medicine.disease 030104 developmental biology Genetic Loci COHORT PROFILE MESH: Female 0301 basic medicine MESH: Premature Birth Nutrition and Disease lcsh:Medicine Reproductive health and childbirth MESH: DNA Methylation Voeding en Ziekte 2.1 Biological and endogenous factors RUNX3 GENE Genetics (clinical) RISK Pediatric MESH: Infant Newborn MESH: DNA Gestational age Premature birth Cord blood DNA methylation Premature Birth Molecular Medicine Female Life Sciences & Biomedicine MESH: Fetal Development MESH: Infant Premature lcsh:QH426-470 Adolescent [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics MESH: Genetic Loci [SDV.MHEP.PED] Life Sciences [q-bio]/Human health and pathology/Pediatrics medicine Preschool [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics Fetus business.industry Research Human Genome Infant Newborn CHILDHOOD ASTHMA 1103 Clinical Sciences Preterm birth Perinatal Period - Conditions Originating in Perinatal Period Newborn MESH: Male lcsh:Genetics [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics 3111 Biomedicine WEIGHT business |
| Zdroj: | Merid, S K, Novoloaca, A, Sharp, G C, Kupers, L K, Kho, A T, Roy, R, Gao, L, Annesi-Maesano, I, Jain, P, Plusquin, M, Kogevinas, M, Allard, C, Vehmeijer, F O, Kazmi, N, Salas, L A, Rezwan, F I, Zhang, H, Sebert, S, Czamara, D, Rifas-Shiman, S L, Melton, P E, Lawlor, D A, Pershagen, G, Breton, C V, Huen, K, Baiz, N, Gagliardi, L, Nawrot, T S, Corpeleijn, E, Perron, P, Duijts, L, Nohr, E A, Bustamante, M, Ewart, S L, Karmaus, W, Zhao, S, Page, C M, Herceg, Z, Jarvelin, M-R, Lahti, J, Baccarelli, A A, Anderson, D, Kachroo, P, Relton, C L, Bergstrom, A, Eskenazi, B, Soomro, M H, Vineis, P, Snieder, H, Bouchard, L, Jaddoe, V W, Sørensen, T I A, Vrijheid, M, Arshad, S H, Holloway, J W, Haberg, S E, Magnus, P, Dwyer, T, Binder, E B, DeMeo, D L, Vonk, J M, Newnham, J, Tantisira, K G, Kull, I, Wiemels, J L, Heude, B, Sunyer, J, Nystad, W, Munthe-Kaas, M C, Raikkonen, K, Oken, E, Huang, R-C, Weiss, S T, Anto, J M, Bousquet, J, Kumar, A, Soderhall, C, Almqvist, C, Cardenas, A, Gruzieva, O, Xu, C-J, Reese, S E, Kere, J, Brodin, P, Solomon, O, Wielscher, M, Holland, N, Ghantous, A, Hivert, M-F, Felix, J F, Koppelman, G H, London, S J & Melen, E 2020, ' Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age ', Genome Medicine, vol. 12, no. 1, 25 . https://doi.org/10.1186/s13073-020-0716-9 Genome medicine, vol 12, iss 1 Article Genome Medicine, Vol 12, Iss 1, Pp 1-17 (2020) Merid, S K, Novoloaca, A, Sharp, G C, Küpers, L K, Kho, A T, Roy, R, Gao, L, Annesi-Maesano, I, Jain, P, Plusquin, M, Kogevinas, M, Allard, C, Vehmeijer, F O, Kazmi, N, Salas, L A, Rezwan, F I, Zhang, H, Sebert, S, Czamara, D, Rifas-Shiman, S L, Melton, P E, Lawlor, D A, Pershagen, G, Breton, C V, Huen, K, Baiz, N, Gagliardi, L, Nawrot, T S, Corpeleijn, E, Perron, P, Duijts, L, Nohr, E A, Bustamante, M, Ewart, S L, Karmaus, W, Zhao, S, Page, C M, Herceg, Z, Jarvelin, M R, Lahti, J, Baccarelli, A A, Anderson, D, Kachroo, P, Relton, C L, Bergström, A, Eskenazi, B, Soomro, M H, Vineis, P, Snieder, H, Bouchard, L, Jaddoe, V W, Sørensen, T I A, Vrijheid, M, Arshad, S H, Holloway, J W, Håberg, S E, Magnus, P, Dwyer, T, Binder, E B, Demeo, D L, Vonk, J M, Newnham, J, Tantisira, K G, Kull, I, Wiemels, J L, Heude, B, Sunyer, J, Nystad, W, Munthe-Kaas, M C, Raïkkönen, K, Oken, E, Huang, R C, Weiss, S T, Antó, J M, Bousquet, J, Kumar, A, Söderhäll, C, Almqvist, C, Cardenas, A, Gruzieva, O, Xu, C J, Reese, S E, Kere, J, Brodin, P, Solomon, O, Wielscher, M, Holland, N, Ghantous, A, Hivert, M F, Felix, J F, Koppelman, G H, London, S J & Melén, E 2020, ' Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age ', Genome Medicine, vol. 12, no. 1, 25 . https://doi.org/10.1186/s13073-020-0716-9 Genome medicine, 12(1):25. BMC Merid, S K, Sharp, G C, Küpers, L K, Kazmi, N, Lawlor, D A, Relton, C L, Sørensen, T I A & al., E 2020, ' Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age ', Genome Medicine, vol. 12, 25 (2020) . https://doi.org/10.1186/s13073-020-0716-9 Genome Medicine, 12(1) Genome Medicine Genome Medicine, 2020, 12 (1), pp.25. ⟨10.1186/s13073-020-0716-9⟩ Genome Medicine, 12(1):25. BioMed Central Ltd. Genome Medicine 12 (2020) 1 |
| ISSN: | 1756-994X |
| Popis: | Background Preterm birth and shorter duration of pregnancy are associated with increased morbidity in neonatal and later life. As the epigenome is known to have an important role during fetal development, we investigated associations between gestational age and blood DNA methylation in children. Methods We performed meta-analysis of Illumina’s HumanMethylation450-array associations between gestational age and cord blood DNA methylation in 3648 newborns from 17 cohorts without common pregnancy complications, induced delivery or caesarean section. We also explored associations of gestational age with DNA methylation measured at 4–18 years in additional pediatric cohorts. Follow-up analyses of DNA methylation and gene expression correlations were performed in cord blood. DNA methylation profiles were also explored in tissues relevant for gestational age health effects: fetal brain and lung. Results We identified 8899 CpGs in cord blood that were associated with gestational age (range 27–42 weeks), at Bonferroni significance, P − 7, of which 3343 were novel. These were annotated to 4966 genes. After restricting findings to at least three significant adjacent CpGs, we identified 1276 CpGs annotated to 325 genes. Results were generally consistent when analyses were restricted to term births. Cord blood findings tended not to persist into childhood and adolescence. Pathway analyses identified enrichment for biological processes critical to embryonic development. Follow-up of identified genes showed correlations between gestational age and DNA methylation levels in fetal brain and lung tissue, as well as correlation with expression levels. Conclusions We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues. These findings may contribute to understanding mechanisms linking gestational age to health effects. |
| Databáze: | OpenAIRE |
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