Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Comprehensive Review

Autor: Brett A. Lidbury, Claudia T. Silva-Aldana, Mauricio Arcos-Burgos, Claudio A. Mastronardi, Mateo Cortes Rivera
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Hydrocortisone
Encephalomyelitis
Clinical Biochemistry
Neuroimmunology
Autoimmunity
Disease
Review
chronic fatigue syndrome
B lymphocyte subpopulation
Immunoglobulin blood level
0302 clinical medicine
Nervous system inflammation
hypothalamic–pituitary–adrenal axis
Central nervous system disease
education.field_of_study
lcsh:R5-920
Hypothalamic–pituitary–adrenal axis
Epstein Barr virus
Prognosis
myalgic encephalomyelitis
immunological
Immunological
Biomarker (medicine)
biomarker
Epigenetics
Epstein barr virus
lcsh:Medicine (General)
Human
musculoskeletal diseases
neuroimmune
medicine.medical_specialty
Serotonin
Population
MEDLINE
Natural killer cell
Serotoninergic transmission
Neuroimmune
Pathophysiology
World health
Sensitization
Glia cell
03 medical and health sciences
Hypothalamus hypophysis adrenal system
Dna modification
medicine
Chronic fatigue syndrome
Immunoglobulin
Neurotransmitter
Myalgic encephalomyelitis
Intensive care medicine
education
Cell activation
Inflammation
Ribonuclease l
business.industry
Genetic predisposition
Neuroendocrinology
Biomarker
medicine.disease
2'
5' oligoadenylate synthetase
Immune dysregulation
030104 developmental biology
Immune system
Clinical feature
Oxidative stress
Hydrocortisone blood level
Age of onset
business
030217 neurology & neurosurgery
Zdroj: Diagnostics, Vol 9, Iss 3, p 91 (2019)
Diagnostics
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
ISSN: 2075-4418
Popis: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic disease of unknown aetiology that is recognized by the World Health Organization (WHO) and the United States Center for Disease Control and Prevention (US CDC) as a disorder of the brain. The disease predominantly affects adults, with a peak age of onset of between 20 and 45 years with a female to male ratio of 3:1. Although the clinical features of the disease have been well established within diagnostic criteria, the diagnosis of ME/CFS is still of exclusion, meaning that other medical conditions must be ruled out. The pathophysiological mechanisms are unclear but the neuro-immuno-endocrinological pattern of CFS patients gleaned from various studies indicates that these three pillars may be the key point to understand the complexity of the disease. At the moment, there are no specific pharmacological therapies to treat the disease, but several studies’ aims and therapeutic approaches have been described in order to benefit patients’ prognosis, symptomatology relief, and the recovery of pre-existing function. This review presents a pathophysiological approach to understanding the essential concepts of ME/CFS, with an emphasis on the population, clinical, and genetic concepts associated with ME/CFS. © 2019 by the authors.
Databáze: OpenAIRE
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