Enhancement of bone formation in an experimental bony defect using ferumoxide-labelled mesenchymal stromal cells and a magnetic targeting system
| Autor: | Yu Mochizuki, T. Kobayashi, Mitsuo Ochi, Yuji Yasunaga, Masakazu Ishikawa, Seigo Oshima |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Ceramics
Stromal cell Nonunion Cell Culture Techniques chemistry.chemical_element Biocompatible Materials Calcium Mesenchymal Stem Cell Transplantation Magnetics Cell Movement Osteogenesis Bone cell medicine Animals Orthopedics and Sports Medicine Bone formation Magnetite Nanoparticles Fracture Healing business.industry Mesenchymal stem cell Dextrans Anatomy medicine.disease Ulna Fractures Ferumoxide Radiography Disease Models Animal Durapatite chemistry Bone Substitutes Surgery Rabbits Stromal Cells business Infiltration (medical) Biomedical engineering |
| Zdroj: | The Journal of bone and joint surgery. British volume. 92(11) |
| ISSN: | 2044-5377 |
| Popis: | We used interconnected porous calcium hydroxyapatite ceramic to bridge a rabbit ulnar defect. Two weeks after inducing the defect we percutaneously injected rabbit bone marrow-derived mesenchymal stromal cells labelled with ferumoxide. The contribution of an external magnetic targeting system to attract these cells into the ceramic and their effect on subsequent bone formation were evaluated. This technique significantly facilitated the infiltration of ferumoxide-labelled cells into ceramic and significantly contributed to the enhancement of bone formation even in the chronic phase. As such, it is potentially of clinical use to treat fractures, bone defects, delayed union and nonunion. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|