Pregnancy of patients with idiopathic thrombocytopenic purpura: maternal and neonatal outcomes
| Autor: | Serdinç Özdoğan, Şafak Yılmaz Baran, Seda Yüksel Şimşek, Hakan Kalaycı, Gülşen Doğan Durdağ, Songül Alemdaroğlu, Esra Bulgan Kilicdag |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Birth weight medicine.medical_treatment Splenectomy lcsh:Medicine thrombocytopenia lcsh:Gynecology and obstetrics 03 medical and health sciences neonatal thrombocytopenia 0302 clinical medicine immune system diseases hemic and lymphatic diseases medicine lcsh:RG1-991 Original Investigation Autoimmune disease Fetus Pregnancy 030219 obstetrics & reproductive medicine business.industry lcsh:R Obstetrics and Gynecology Retrospective cohort study medicine.disease Thrombocytopenic purpura idiopathic thrombocytopenic purpura 030220 oncology & carcinogenesis pregnancy Differential diagnosis business |
| Zdroj: | Journal of the Turkish-German Gynecological Association, Vol 21, Iss 2, Pp 97-101 (2020) Journal of the Turkish German Gynecological Association |
| ISSN: | 1309-0380 1309-0399 |
| Popis: | Objective Thrombocytopenia occurs in 7% of pregnant women. Along with other causes, idiopathic thrombocytopenic purpura (ITP), which is an autoimmune disease with autoantibodies causing platelet destruction, must be considered in the differential diagnosis. Antiplatelet antibodies can cross the placenta and cause thrombocytopenia in the newborn. The aim of our study was to assess the management of ITP in pregnancy, and to investigate neonatal outcomes. Material and methods This retrospective study was conducted in a tertiary center including 89 pregnant patients with ITP followed between October 2011 and January 2018. Patients were evaluated in two groups according to diagnoses of ITP and chronic ITP. Age, obstetric history, ITP diagnosis, and follow-up period, presence of splenectomy, platelet count during pregnancy and after birth, treatment during pregnancy, route of delivery, weight and platelet count of newborn, sign of hemorrhage, and fetal congenital anomaly were assessed. Results Considering the ITP and chronic ITP groups, no significant difference was seen with respect to parity, timing of delivery, preoperative and postoperative platelet counts, and hemoglobin values. Route of delivery, birth weight, APGAR scores, newborn platelet count, and congenital anomaly rates were also similar. The timing of treatment was different because patients whose diagnoses were established during pregnancy were mostly treated for preparation of delivery. Treatment modalities were similar. Conclusion Probability of severe thrombocytopenia at delivery is higher in patients with ITP who are diagnosed during pregnancy when compared with patients who received prepregnancy diagnoses. ITP is an important disease for both the mother and newborn. Patients should be followed closely in cooperation with the hematology department. |
| Databáze: | OpenAIRE |
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