Glucose-induced Insulin Response is Reduced and Proinsulin Response Increased in Healthy Siblings of Type 1 Diabetic Patients
| Autor: | F Lindgren, B.E. Persson, Svend G Hartling, Suad Efendic, C. Binder, Gisela Dahlquist |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Blood Glucose
Male endocrine system medicine.medical_specialty Time Factors Adolescent endocrine system diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Prohormone Endocrinology HLA Antigens Reference Values Internal medicine Diabetes mellitus Insulin Secretion Internal Medicine medicine Humans Insulin Infusions Intravenous Pancreatic hormone Proinsulin Type 1 diabetes Glucose tolerance test geography geography.geographical_feature_category C-Peptide Insulin Regular Pork medicine.diagnostic_test business.industry Histocompatibility Testing Fasting medicine.disease Islet Kinetics Diabetes Mellitus Type 1 Glucose Haplotypes Female Somatostatin business medicine.drug |
| Zdroj: | Diabetic Medicine. 8:638-643 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1111/j.1464-5491.1991.tb01670.x |
| Popis: | Glucose-stimulated insulin and proinsulin responses, and insulin sensitivity, were studied in 30 HLA identical, 38 HLA haplo-identical, and 25 HLA non-identical, healthy islet-cell-antibody negative siblings of Type 1 diabetic patients. The results were compared with 41 age- and sex-matched healthy subjects with no diabetes in the family. The proinsulin-corrected insulin response to an intravenous glucose infusion test was significantly lower among siblings when insulin sensitivity was taken into account (1.65 (inter-quartile range 1.20-2.64) vs 2.18 (1.65-3.28) nmol mmol-1 min, p = 0.04). Proinsulin values were consistently higher among siblings than among control subjects (peak values 50.0 vs 38.0 pmol l-1 (p = 0.004)). When proinsulin release was corrected for individual insulin sensitivity this difference remained. The results suggest disturbed islet B-cell function, unrelated to HLA identity or the presence of circulating islet cell antibodies. |
| Databáze: | OpenAIRE |
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