Effects on haemoglobin of multi-micronutrient supplementation and multi-helminth chemotherapy: a randomized, controlled trial in Kenyan school children
| Autor: | E Muniu, Frederick Thiong'o, B Omondi, Henrik Friis, Pascal Magnussen, Paul Wenzel Geissler, K Fleischer Michaelsen, David L. Mwaniki, John H. Ouma |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Vitamin
medicine.medical_specialty Adolescent Population Medicine (miscellaneous) Albendazole Gastroenterology Praziquantel law.invention Placebos Hemoglobins Hookworm Infections chemistry.chemical_compound Double-Blind Method Randomized controlled trial law Internal medicine parasitic diseases medicine Animals Humans Micronutrients Trichuriasis Ascaris lumbricoides Child education Anthelmintics Ascariasis education.field_of_study Schools Nutrition and Dietetics business.industry Retinol Anemia medicine.disease Micronutrient Kenya Schistosomiasis mansoni Malaria Vitamin A deficiency chemistry Dietary Supplements Immunology business medicine.drug |
| Zdroj: | European Journal of Clinical Nutrition. 57:573-579 |
| ISSN: | 1476-5640 0954-3007 |
| DOI: | 10.1038/sj.ejcn.1601568 |
| Popis: | OBJECTIVE: To assess the effects of multi-micronutrient supplementation and multi-helminth chemotherapy on serum retinol concentration, using schools as a health delivery system. STUDY AREA AND POPULATION: From 19 primary schools in Bondo District, western Kenya, 977 children between 9 and 18 y were included in the trial. The 644 (65.9%) children on whom baseline serum retinol was available were included in this study. DESIGN: A randomised, placebo-controlled, double-blind, two-by-two factorial trial on the effects of multi-micronutrient supplementation and multi-helminth chemotherapy on serum retinol after 8 months. INTERVENTION: Single treatment with albendazole (600 mg) and praziquantel (40 mg/kg of body weight) and daily multi-micronutrient supplementation with tablet containing 1000 microg vitamin A. RESULTS: Micronutrient supplementation (0.08 micromol/l, 95% CI 0.01, 0.14; P=0.025), but not treatment (0.03 micromol/l, 95% CI -0.04, 0.10; P=0.38), increased serum retinol. However, treatment did increase serum retinol in S. mansoni-infected (0.09, 95% CI 0.02, 0.16; P=0.009), but not in uninfected children (-0.07, 95% CI -0.18, 0.03; P=0.18; interaction, P=0.01). Similarly, reduction in egg output of S. mansoni, but none of the geohelminth, was a predictor, corresponding to a 0.008 micromol/l (95% CI 0.00002, 0.02; P=0.049) increase in serum retinol per 100 epg reduction. Interestingly, interactions were found between age and sex (P=0.046), and malaria parasitaemia and sickle cell phenotype (P=0.04). CONCLUSION: Multi-micronutrient supplementation and reduction in S. mansoni egg output increased serum retinol, irrespective of initial serum retinol. SPONSORSHIP: The Danish International Development Assistance. |
| Databáze: | OpenAIRE |
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