Flying Fox Hemolytic Fever, Description of a New Zoonosis Caused by Candidatus Mycoplasma haemohominis
| Autor: | Denise Desoutter, Julien Colot, Elise Klement-Frutos, Cécile Cazorla, Vincent Bossi, Pierre-Edouard Fournier, Malik Oedin, Bernard Davoust, Elodie Descloux, Anthony Levasseur, Sylvie Laumond, Martine Chauvet, Isabelle Mermoud, Didier Raoult, Ann-Claire Gourinat, Oleg Mediannikov, A. Merlet, Fabrice Brescia, Marie-Amélie Goujart, Luca Antonini |
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| Přispěvatelé: | Centre hospitalier territorial Gaston-Bourret [Dumbea] (CHT), Centre hospitalier territorial Gaston-Bourret [Nouméa], Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Assistance Publique - Hôpitaux de Marseille (APHM), Institut Hospitalier Universitaire Méditerranée Infection (IHU Marseille), Groupe Bactériologie Expérimentale [Nouméa, Nouvelle-Calédonie], Institut Pasteur de Nouvelle-Calédonie, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Direction des Affaires Vétérinaires, Alimentaires et Rurales (DAVAR), CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN), Institut Agronomique Néo-Calédonien (IAC), Direction des Affaires sanitaires et sociales de la Nouvelle-Calédonie [Nouméa] (DASS [Nouméa]), Vecteurs - Infections tropicales et méditerranéennes (VITROME), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut de Recherche Biomédicale des Armées [Brétigny-sur-Orge] (IRBA), This work was supported by Public Health Funds from New Caledonia, the Méditerranée-Infection Foundation and the French Agence Nationale de la Recherche under reference Investissements d’Avenir Méditerranée Infection 10-IAHU-03, and Région Provence-Alpes-Côte d’Azur and European funding Fonds européen de développement régional (FEDER) IHUBIOTK., ANR-10-IAHU-0003,Méditerranée Infection,I.H.U. Méditerranée Infection(2010), Institut de Recherche Biomédicale des Armées (IRBA)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Anemia 030106 microbiology bats medicine.disease_cause 03 medical and health sciences MESH: Mycoplasma Mycoplasma New Caledonia [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases Chiroptera medicine Flying fox (fish) Animals Humans Mycoplasma Infections MESH: Animals MESH: Phylogeny Phylogeny autoimmune hemolytic anemia Retrospective Studies hemophagocytosis Candidatus Mycoplasma haemohominis MESH: Humans biology business.industry Zoonosis MESH: Chiroptera MESH: Retrospective Studies MESH: Mycoplasma Infections medicine.disease biology.organism_classification Pteropus Virology 3. Good health Nycteribiidae 030104 developmental biology Infectious Diseases Candidatus Autoimmune hemolytic anemia business |
| Zdroj: | Clinical Infectious Diseases Clinical Infectious Diseases, 2021, 73 (7), pp.e1445-e1453. ⟨10.1093/cid/ciaa1648⟩ Clinical Infectious Diseases, Oxford University Press (OUP), 2021, 73 (7), pp.e1445-e1453. ⟨10.1093/cid/ciaa1648⟩ |
| ISSN: | 1058-4838 1537-6591 |
| DOI: | 10.1093/cid/ciaa1648⟩ |
| Popis: | Background Hemotropic mycoplasmas, previously classified in the genus Eperythrozoon, have been reported as causing human infections in Brazil, China, Japan, and Spain. Methods In 2017, we detected DNA from Candidatus Mycoplasma haemohominis in the blood of a Melanesian patient from New Caledonia presenting with febrile splenomegaly, weight loss, life-threatening autoimmune hemolytic anemia, and hemophagocytosis. The full genome of the bacterium was sequenced from a blood isolate. Subsequently, we retrospectively (2011–2017) and prospectively (2018–2019) tested patients who had been hospitalized with a similar clinico-biological picture. In addition, as these patients had been in contact with frugivorous bats (authorized under conditions for hunting and eating in New Caledonia), we investigated the role of these animals and their biting flies by testing them for hemotropic mycoplasmas. Results There were 15 patients found to be infected by this hemotropic mycoplasma. Among them, 4 (27%) died following splenectomy performed either for spontaneous spleen rupture or to cure refractory autoimmune hemolytic anemia. The bacterium was cultivated from the patient’s blood. The full genome of the Neocaledonian Candidatus M. haemohominis strain differed from that of a recently identified Japanese strain. Of 40 tested Pteropus bats, 40% were positive; 100% of collected bat flies Cyclopodia horsfieldi (Nycteribiidae, Diptera) were positive. Human, bat, and dipteran strains were highly similar. Conclusions The bacterium being widely distributed in bats, Candidatus M. haemohominis, should be regarded as a potential cause of severe infections in humans. |
| Databáze: | OpenAIRE |
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