Effect of MAPT and APOE on prognosis of progressive supranuclear palsy
| Autor: | Yasuhiko Baba, N Thomas, Zbigniew K. Wszolek, Yoshio Tsuboi, Dennis W. Dickson, Keith A. Josephs, John D. Putzke |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Apolipoprotein E Pathology medicine.medical_specialty Genotype Disease duration Apolipoprotein E4 tau Proteins Gastroenterology Disease course Progressive supranuclear palsy Apolipoproteins E Sex Factors Internal medicine medicine Humans Age of Onset Risk factor Allele Aged General Neuroscience Haplotype Prognosis medicine.disease Haplotypes Linear Models Regression Analysis Female Supranuclear Palsy Progressive Psychology |
| Zdroj: | Neuroscience Letters. 405:116-119 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2006.06.032 |
| Popis: | To assess genetic influence on the clinical presentation of progressive supranuclear palsy (PSP), the genetic effect on disease course was examined for variants in the tau gene (MAPT) and the gene for apolipoprotein E (APOE) in 58 cases of pathologically confirmed PSP. Clinical indicators of disease course included age at symptomatic onset (AAO), age at death (AAD), and disease duration (DD) and the genetic effects examined included MAPT haplotypes and APOE genotypes. From linear regression analysis, the MAPT H1/H1 genotype was associated with significantly earlier AAO (P = 0.038). The MAPT genotype did not significantly influence DD or AAD. The APOE ɛ4 allele did not significantly influence AAO, AAD, or DD. Male sex was a predictor for earlier AAO (P = 0.015). The interaction between MAPT and APOE was not significant for AAD and DD, but a significant negative coefficient was found for AAO suggesting their combination does not have an additive effect. These results support the assertion that the H1/H1 genotype may contribute to the earlier occurrence of clinical symptoms. |
| Databáze: | OpenAIRE |
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