Interleukin-18 promoter polymorphisms and the disease progression of Hepatitis B virus-related liver disease
| Autor: | Osamu Segawa, Katsumi Eguchi, Minoru Nakamura, Yumi Maeda, Mika Sugiura, Hiromi Ishibashi, Eiji Kawasaki, Seigo Abiru, Susumu Kondoh, Hideji Tajima, Masayuki Machida, Hiroshi Yatsuhashi, Kazumi Sawakami-Kobayashi, Koji Yano, Kazuhiko Nakao, Kiyoshi Migita, Ryoko Kawasumi |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male HBsAg Cirrhosis Genotype medicine.disease_cause Polymorphism Single Nucleotide Liver disease Orthohepadnavirus Physiology (medical) medicine Humans Genetic Predisposition to Disease Promoter Regions Genetic Aged Hepatitis B virus biology Biochemistry (medical) Interleukin-18 Public Health Environmental and Occupational Health virus diseases General Medicine Middle Aged Hepatitis B medicine.disease biology.organism_classification digestive system diseases Hepadnaviridae Hepatocellular carcinoma Carrier State Immunology Disease Progression Female |
| Zdroj: | Translational Research. 153:91-96 |
| ISSN: | 1931-5244 |
| DOI: | 10.1016/j.trsl.2008.11.008 |
| Popis: | In this study, we aimed to explore whether interleukin-18 (IL-18) gene-promoter polymorphisms are associated with the outcome of hepatitis B virus (HBV) infection. In all, 204 chronically HBV-infected patients were recruited in this study. Of the 204 HBV-infected patients, 43 were considered to be inactive HBV carriers based on the sustained normalization of serum alanine aminotransferase (ALT) together with seropositivity for the antibody to hepatitis B e-antigen (anti-HBe). A total of 161 patients were found to have chronic progressive liver disease, which included cirrhosis. In these HBV-infected patients, the frequencies of AA genotype of IL-18 gene-promoter polymorphisms at position -607 and C allele at position -137 were significantly higher in inactive HBV carriers compared with those in patients with chronic progressive liver disease. These polymorphisms of the IL-18 promoter regions (-607 and -137) could be associated with different outcomes of HBV infection. |
| Databáze: | OpenAIRE |
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