Cut-off value for normal versus abnormal right-to-left shunt percentages using (99m)Tc-macroaggregated albumin
| Autor: | Akihiko Ishibashi, Takuya Mitsumoto, Kimiteru Ito, Kyoko Kurihara, Kazuo Kubota, Miyako Morooka, Ryogo Minamimoto |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male Right-to-left shunt Perfusion Imaging Kidney Coronary circulation Lung perfusion scintigraphy Reference Values medicine.artery Coronary Circulation medicine Humans Radiology Nuclear Medicine and imaging Whole Body Imaging Heart Atria Lung Technetium Tc 99m Aggregated Albumin Aged business.industry Cut off value Albumin Kidney metabolism Brain Biological Transport General Medicine Middle Aged Shunt (medical) medicine.anatomical_structure Macroaggregated albumin Female business Nuclear medicine |
| Zdroj: | Nuclear medicine communications. 32(10) |
| ISSN: | 1473-5628 |
| Popis: | To determine the cut-off value for distinguishing a normal versus an abnormal right-to-left shunt percentage on lung perfusion scintigraphy using (99m)Tc-macroaggregated albumin (MAA).Fifty-three patients (eight patients with a right-to-left shunt and 45 without a right-to-left shunt) who underwent MAA whole-body imaging for the evaluation of right-to-left shunts were divided into group 1 (eight patients with brain MAA uptake) and group 2 (45 patients without brain MAA uptake). Moreover, group 2 was subdivided into two categories (groups 2a and 2b) based on the results of lung computed tomography, electrocardiography examinations, and pulmonary function tests. The average and standard deviation (SD) of each group were compared. In addition, we estimated the cut-off value for a normal right-to-left shunt percentage using whole-body imaging.The average right-to-left shunt percentage values and SD were 23.67±12.17% in group 1, 6.68±1.04% in group 2a, and 6.60±0.84% in group 2b. The shunt percentages of groups 2a and 2b were not significantly different (P=0.77). The estimated normal value (mean±2 SD) of group 2 was 6.64±0.94%. Meanwhile, the cut-off value was estimated as 10% based on the distributions of MAA shunt percentages for groups 1 and 2.The normal range (mean±2 SD) was 6.64±1.88%. The cut-off value for the normal right-to-left shunt percentage in MAA scintigraphy was 10%. |
| Databáze: | OpenAIRE |
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