Children Born to Mothers with Rash During Zika Virus Epidemic in Brazil: First 18 Months of Life
| Autor: | Ana Flávia Malheiros Torbey, Armanda de Oliveira Pache de Farias, Luiz Antonio Bastos Camacho, Aurea Lucia Alves de Azevedo Grippa de Souza, Kathryn L. Lovero, Lee W. Riley, Teresa Santos, Claudete Aparecida Araújo Cardoso, Luiz Cláudio Santos de Souza Lima, Alexandre Ribeiro Fernandes, Arnaldo Costa Bueno, Renata Artimos de Oliveira Vianna, Maria Dolores Salgado Quintans, Fabiana Rabe Carvalho, Solange Oliveira |
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| Rok vydání: | 2019 |
| Předmět: |
Pediatrics
medicine.medical_specialty Microcephaly Developmental Disabilities Mothers Asymptomatic Zika virus Disability Evaluation 03 medical and health sciences Epilepsy 0302 clinical medicine Pregnancy medicine Humans Pregnancy Complications Infectious Epidemics 030304 developmental biology 0303 health sciences biology Reverse Transcriptase Polymerase Chain Reaction Zika Virus Infection business.industry Infant Newborn Infant Zika Virus Exanthema medicine.disease biology.organism_classification Original Papers Rash Infectious Diseases Pediatrics Perinatology and Child Health Gestation Female Observational study medicine.symptom business Brazil 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | J Trop Pediatr |
| ISSN: | 1465-3664 |
| DOI: | 10.1093/tropej/fmz019 |
| Popis: | Objective To better understand the clinical spectrum and course of congenital Zika syndrome (CZS) during the first 18 months of life of children whose mothers had rash during pregnancy. Methods This longitudinal observational study evaluated the clinical progress from birth until 18 months of life of children of mothers who developed rash during or up to 3 months before gestation. Maternal rash occurred from November 2015 to May 2017. The study subjects were divided into three groups: children whose mothers tested positive by RT-qPCR for Zika virus (ZIKV) (Group 1), children whose mothers tested negative by RT-qPCR for ZIKV (Group 2), and children whose mothers did not undergo any testing for ZIKV (Group 3) but tested negative for other congenital infections. Results Between April 2016 and July 2018, we studied 108 children: 43 in Group 1, 26 in Group 2 and 39 in Group 3. The majority of children were admitted into the study within 6 months of life. CZS was diagnosed in 26 children, equally distributed in Groups 1 and 3. Of 18 children with microcephaly, 6 were in Group 1 (1 postnatal) and 12 were in Group 3 (5 postnatal). Maternal rash frequency was 10 times higher during the first trimester than in the other trimesters (OR: 10.35; CI 95%: 3.52–30.41). CZS was diagnosed during the follow-up period in 14 (54%) cases. Developmental delays and motor abnormalities occurred in all children and persisted up to 18 months. Epilepsy occurred in 18 (69%) of the cases. Conclusions Infants born of mothers exposed to ZIKV during pregnancy showed progression of developmental, motor and neurologic abnormalities even if they were born asymptomatic. Continued postnatal monitoring of such newborns is necessary to preclude disability-associated complications. |
| Databáze: | OpenAIRE |
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