Co-conjugation of Virulence Plasmid and KPC Plasmid in a Clinical Klebsiella pneumoniae Strain
| Autor: | Chen Yang, Rong Zhang, Xiaoxuan Liu, Edward Wai-Chi Chan, Xuemei Yang, Ning Dong, Lianwei Ye, Sheng Chen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
biology Strain (chemistry) Klebsiella pneumoniae transmission Virulence biology.organism_classification medicine.disease_cause medicine.disease conjugative virulence plasmid Microbiology QR1-502 chemistry.chemical_compound Plasmid chemistry blaKPC-bearing plasmid CR-HvKP medicine Aerobactin Klebsiella pneumonia IncFIB/IncHI1B Gene Escherichia coli |
| Zdroj: | Frontiers in Microbiology, Vol 12 (2021) |
| Popis: | Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) strains have been increasingly reported, and it is important to understand the evolutionary mechanisms of these highly pathogenic and resistant bacterial pathogens. In this study, we characterized a ST11 carbapenem-resistant K. pneumoniae strain which harbored an IncFIB/IncHI1B type virulence plasmid and an IncFII/IncR type blaKPC–2-bearing plasmid. The virulence plasmid was found to be conjugative and harbored a 35-kbp fragment including aerobactin encoding cluster from virulence plasmid pLVPK and multiple resistance genes, resulting in a mosaic multi-drug resistance and virulence plasmid. This virulence plasmid could be transferred via conjugation to Escherichia coli and K. pneumoniae strains alone as well as together with the blaKPC–2-bearing plasmid. Co-transmission of virulence and blaKPC–2-bearing plasmids would directly convert a classic K. pneumoniae strain into CR-HvKP strain, leading to a sharp increase in the prevalence of CR-HvKP in clinical settings, which poses a great threat to human health. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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