Somatic deficiency causes reproductive parasitism in a fungus
| Autor: | Duur K. Aanen, Cristina Berenguer Millanes, Joost van den Heuvel, Alfons J. M. Debets, Alexey A. Grum-Grzhimaylo, Eric Bastiaans |
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| Přispěvatelé: | Microbial Ecology (ME) |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Somatic cell Science DNA Mutational Analysis Genes Fungal Hyphae General Physics and Astronomy Laboratorium voor Erfelijkheidsleer General Biochemistry Genetics and Molecular Biology Germline Article Neurospora crassa Cell Fusion Evolution Molecular Fungal Proteins 03 medical and health sciences Fungal biology Gene Knockout Techniques 0302 clinical medicine Life Science Evolutionary dynamics Experimental evolution Social evolution Multidisciplinary biology fungi national General Chemistry PE&RC biology.organism_classification Genetic load Somatic fusion Multicellular organism 030104 developmental biology Evolutionary biology Mutation Laboratory of Genetics Plan_S-Compliant_OA 030217 neurology & neurosurgery |
| Zdroj: | Nature Communications Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021) Nature Communications 12 (2021) 1 Nature Communications, 12:783. Nature Publishing Group Nature Communications, 12(1) |
| ISSN: | 2041-1723 |
| Popis: | Some multicellular organisms can fuse because mergers potentially provide mutual benefits. However, experimental evolution in the fungus Neurospora crassa has demonstrated that free fusion of mycelia favours cheater lineages, but the mechanism and evolutionary dynamics of this exploitation are unknown. Here we show, paradoxically, that all convergently evolved cheater lineages have similar fusion deficiencies. These mutants are unable to initiate fusion but retain access to wild-type mycelia that fuse with them. This asymmetry reduces cheater-mutant contributions to somatic substrate-bound hyphal networks, but increases representation of their nuclei in the aerial reproductive hyphae. Cheaters only benefit when relatively rare and likely impose genetic load reminiscent of germline senescence. We show that the consequences of somatic fusion can be unequally distributed among fusion partners, with the passive non-fusing partner profiting more. We discuss how our findings may relate to the extensive variation in fusion frequency of fungi found in nature. Mycelial fusion can favour fungal strains that exploit each other, but the mechanism is not well understood. Here, Grum-Grzhimaylo et al. show that different cheater lineages share similar deficiencies in initiating fusion that nevertheless enable them to preferentially obtain the benefits of fusion initiated by wild-type mycelia. |
| Databáze: | OpenAIRE |
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