Incidence, prevalence and long-term progression of Goh algorithm rated interstitial lung disease in systemic sclerosis in two independent cohorts in flanders: A retrospective cohort study
| Autor: | Frédéric Houssiau, Filip De Keyser, Yves Piette, Koen Verbeke, Carolien Bonroy, Amber Vanhaecke, Rene Westhovens, Ellen De Langhe, Daniel Engelbert Blockmans, Wim A. Wuyts, Karin Melsens, Guy Brusselle, Charlotte Carton, Vanessa Smith, Marie Vanthuyne, Els Vandecasteele, Ellen Deschepper |
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| Přispěvatelé: | UCL - SSS/IREC/RUMA - Pôle de Pathologies rhumatismales, UCL - (SLuc) Service de rhumatologie |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
INVOLVEMENT
medicine.medical_specialty SUBSETS Epidemiology Interstitial lung disease CLASSIFICATION FEV1/FVC ratio 6-MINUTE WALK TEST Rheumatology DLCO medicine Medicine and Health Sciences Prevalence Humans CRITERIA skin and connective tissue diseases Lung Retrospective Studies Scleroderma Systemic integumentary system business.industry Incidence (epidemiology) Incidence MORTALITY Retrospective cohort study respiratory system Early systemic sclerosis medicine.disease respiratory tract diseases Anesthesiology and Pain Medicine medicine.anatomical_structure Incidence and progression Systemic sclerosis business Lung Diseases Interstitial Algorithm Algorithms Incidence prevalence |
| Zdroj: | SEMINARS IN ARTHRITIS AND RHEUMATISM Seminars in arthritis and rheumatism, Vol. 51, no. 5, p. 969-976 (2021) |
| ISSN: | 0049-0172 1532-866X |
| Popis: | Objectives: The epidemiology of interstitial lung disease (ILD) in systemic sclerosis (SSc) in Belgium is unknown. In literature, its prevalence varies between 19% and 52% in limited/diffuse cutaneous SSc (LcSSc/ DcSSc). However, its prevalence in "early" SSc (pre-clinically overt SSc without [yet] skin involvement), nor its incidence rate in SSc (LcSSc/DcSSc/"early" SSc) has ever been described. Against this background, we aimed to determine the prevalence/incidence (rate) and progression of ILD in SSc. Methods: 12-year follow-up data of consecutive SSc patients, included in two Flemish cohorts (University Hospitals Ghent and Leuven), were retrospectively analysed. ILD was classified according to the simplified Goh algorithm. Progression of ILD was defined as a relative decline of FVC >10%, a combined relative decline of FVC 5-10% and DLCO >15%, or as an increase in HRCT extent. Results: 722 patients (60% LcSSc/ 20% DcSSc/ 20% "early" SSc, median (IQR) follow-up 39 [12-80] months) had baseline HRCT. 243 were rated to have ILD at baseline and 39 during follow-up (prevalence of 34%/ incidence rate of 20.3/1000PY, 95%CI:14.5-27.8). Amongst those with baseline ILD, 60% had lung functional progression at five years of follow-up. In the "early" SSc subgroup, eight patients were rated to have ILD at baseline and three during follow-up (prevalence of 6%/ incidence rate of 5.8/1000 PY, 95%CI:1.2-17.0). Conclusion: Both LcSSc and DcSSc patients should be monitored for ILD evolution. The low prevalence and incidence of ILD in the "early" SSc subgroup may instruct future decisions on the construction of uniform patient follow-up pathways in "early" SSc. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
| Databáze: | OpenAIRE |
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