Methanol Poisoning as an Acute Toxicological Basal Ganglia Lesion Model: Evidence from Brain Volumetry and Cognition
| Autor: | Tobias Kober, Bénédicte Maréchal, Irena Liskova, Daniela Pelclova, Z. Seidl, Jiří Klempíř, Hana Brožová, Sergey Zakharov, Kateřina Bukačová, Ondrej Bezdicek, Kamila Poláková, Evžen Růžička, Manuela Vaneckova, Michal Miovský, Josef Mana |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Trail Making Test 030508 substance abuse Medicine (miscellaneous) Physiology Neuropsychological Tests Toxicology Basal Ganglia White matter Executive Function 03 medical and health sciences Cognition 0302 clinical medicine Memory Basal ganglia Humans Learning Medicine Attention Survivors Effects of sleep deprivation on cognitive performance Aged business.industry Methanol Putamen Neuropsychology Brain Middle Aged Magnetic Resonance Imaging White Matter Psychiatry and Mental health Cross-Sectional Studies Globus pallidus medicine.anatomical_structure Methanol poisoning Female Nerve Net 0305 other medical science business Psychomotor Performance 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Alcoholism: Clinical and Experimental Research. 43:1486-1497 |
| ISSN: | 1530-0277 0145-6008 |
| DOI: | 10.1111/acer.14077 |
| Popis: | BACKGROUND Acute methanol poisoning leads to optic neuropathy and necrotic lesions of basal ganglia (BG) and subcortical white matter. Survivors of methanol poisoning exhibit long-term executive and memory deficits. Associations between brain volumetry parameters and cognitive sequelae of methanol poisoning are not known. The aim of our study was to identify long-term associations between the cognitive performance of survivors of methanol poisoning and the volume of the brain structures that are selectively vulnerable to methanol. METHODS We conducted a cross-sectional follow-up study on a sample of patients (n = 33, age 50 ± 14 years, 82% males) who survived acute methanol poisoning during methanol mass poisoning outbreak from September 2012 till January 2013 in the Czech Republic. A battery of neuropsychological tests and brain magnetic resonance imaging were included in the clinical examination protocol. Specific brain structures (putamen, globus pallidus, nucleus caudatus, and frontal white matter) were selected as regions of interest, and their volumes were estimated using the MorphoBox prototype software. RESULTS In robust multiple regression models, sustained visual attention performance (as assessed by Trail Making Test and Prague Stroop Test) was positively associated with BG structures and frontal white matter volumes (Wald = 9.03 to 85.50, p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text