Possible enigmatic link between serum leptin and vitiligo with its metabolic derangements: A comparative controlled study
| Autor: | Marwa El-Hawary, Mervat El Ansary, Rania M. Mogawer, Sarah Ibrahim, Samar El-Tahlawi |
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| Rok vydání: | 2021 |
| Předmět: |
Leptin
medicine.medical_specialty Waist Vitiligo Dermatology Body Mass Index Pathogenesis Internal medicine Humans Medicine Obesity skin and connective tissue diseases integumentary system business.industry Incidence (epidemiology) Anthropometry medicine.disease Cross-Sectional Studies Endocrinology Case-Control Studies Obesity Abdominal business Body mass index |
| Zdroj: | Journal of Cosmetic Dermatology. 21:2971-2976 |
| ISSN: | 1473-2165 1473-2130 |
| Popis: | OBJECTIVE Serum leptin, an adipocytokine of interleukin-6 family, has been linked to vitiligo-associated metabolic derangements. Additionally, it has been proposed as an inflammatory mediator with possible influence on vitiligo pathogenesis. This study aimed at assessing serum leptin in vitiligo patients compared to controls and whether different vitiligo characteristics have an influence on serum leptin levels. METHODS In this hospital-based, cross-sectional case-control study, 70 vitiligo (35 segmental vitiligo (SV) and 35 Non-segmental vitiligo (NSV)) and 70 age- and sex-matched controls were assessed for different anthropometric measurements including waist circumference (WC), index of central obesity (ICO), and body mass index (BMI) as well as serum leptin levels. RESULTS Central obesity as per ICO showed no significant difference between patients and controls. Additionally, patients of SV and NSV collectively showed significant higher incidence of +ve serum leptin than their controls (41.4% vs. 22.9%%, P: 0.019). Mere presence of vitiligo and ICO >0.5 were highlighted as independent predictors of +ve serum leptin (P: 0.009 and |
| Databáze: | OpenAIRE |
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